Anti-Mouse DR5/CD262 Antibody (MD5-1)
Based on 1 Customer Validation
Anti-Mouse DR5/CD262 Antibody (MD5-1) is an anti-mouse DR5/CD262 IgG monoclonal antibody. Anti-Mouse DR5/CD262 Antibody (MD5-1) can eliminate myeloid derived suppressor cells (MDSCs) and enhance T cell anti-tumor immunity. Anti-Mouse DR5/CD262 Antibody (MD5-1) can be used for research on cancer such as gastric and colon cancer.
For research use only. We do not sell to patients.
- Purity: 99.20%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Armenian hamster IgG
Mouse
DR5/CD262
Anti-Mouse DR5/CD262 Antibody (MD5-1) (50 μg, i.p., once every 3 days, for 3 times) significantly inhibits tumor growth in female 615 mice bearing MFC tumors or C57BL/6 mice bearing MC38 tumors[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:5×105 EMT-6 cells injected BALB/c mice[1]
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Dosage:50 μg
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Administration:Intraperitoneal injection (i.p.), once every 3 days
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Result:Reduced the number of MDSCs.
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Animal Model:1×106 MFC cells injected female 615 mice (5-7 weeks) or 5×105 MC38 cells injected female C57BL/6 mice (5-7 weeks)[2]
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Dosage:50 μg, combined with PD-L1 mAb (HY-P99145) (200 μg)
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Administration:Intraperitoneal injection (i.p.), once every 3 days, for 3 times
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Result:Significantly inhibited tumor volume.
Significantly prolonged the survival period of mice.
Significantly increased infiltration of CD4+ and CD8+ cells.
Significantly reduced the proportion of MDSC.
Enhanced secretion of IFN-γ and TNF-α.
Had good safety in vivo.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
in vivo induction TRAIL-mediated apoptosis; in vitro induction TRAIL-mediated apoptosis
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse DR5/CD262 Antibody (MD5-1)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (261 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Yi M, et al. Blockade of CCR5+ T Cell Accumulation in the Tumor Microenvironment Optimizes Anti-TGF-β/PD-L1 Bispecific Antibody. Adv Sci (Weinh). 2024 Nov;11(43):e2408598. [Content Brief]
[2]. Tang Y, et al. Targeting depletion of myeloid-derived suppressor cells potentiates PD-L1 blockade efficacy in gastric and colon cancers. Oncoimmunology. 2022 Oct 13;11(1):2131084. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse DR5/CD262 Antibody (MD5-1) Related Classifications
HY-P990249 Related Classifications
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