Anti-Mouse Jagged 2 Antibody (HMJ2-1)
Anti-Mouse Jagged 2 Antibody (HMJ2-1) is an anti-mouse Jagged 2 IgG monoclonal antibody. Anti-Mouse Jagged 2 Antibody (HMJ2-1) regulates Treg/Th17 balance through IL-9. Anti-Mouse Jagged 2 Antibody (HMJ2-1) increases Jagged2-Notch signaling through activation of RBP-Jk. Anti-Mouse Jagged 2 Antibody (HMJ2-1) can be used for researches on inflammation conditions and xenotransplantation such as experimental autoimmune encephalomyelitis (EAE).
For research use only. We do not sell to patients.
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Armenian hamster IgG
Recommend Isotype Controls
Species Reactivity
Mouse
In Vitro
Anti-Mouse Jagged 2 Antibody (HMJ2-1) (20 μg/mL) Slightly enhance osteoclasts derived from mouse bone marrow production, but the effect is not significant[1].
Anti-Mouse Jagged 2 Antibody (HMJ2-1) (5 μg/mL, 1 h) does not significantly inhibit the expression of GLT-1 induced by endothelial cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Anti-Mouse Jagged 2 Antibody (HMJ2-1) (250-500 μg, i.p., on day 0, 2, 4, 6, 8 and 10) has no significant effect on the survival of the transplant in C57BL/6 mice[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MOG35-55 (50 μg) and CFA (HY-153808) induced female C57BL/6 mice (6-8 weeks)[3]
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Dosage:250 μg
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Administration:Intraperitoneal injection (i.p.), once every 2 days for 8 times for the preprocessing group or once daily for 5 days for the synchronous treatment group
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Result:Reduced clinical scores and increased Treg/Th17 ratio for the preprocessing group.
Increased clinical score and decreased Treg/Th17 ratio for the synchronous treatment group.
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Animal Model:C57BL/6 mice (8-12 weeks)[4]
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Dosage:500 μg for initial dose, 250 μg for subsequent doses
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Administration:Intraperitoneal injection (i.p.), on day 0, 2, 4, 6, 8 and 10
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Result:Had no significant impact on the survival of heart transplantation.
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo Jagged 2 neutralization
Chemical Information
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Molecular Weight 150 kDa
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SMILES
[Anti-Mouse Jagged 2 Antibody (HMJ2-1)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Sekine C, et al. Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes. Arthritis Res Ther. 2012 Mar 5;14(2):R45. [Content Brief]
[2]. Martinez-Lozada Z, et al. Reciprocal communication between astrocytes and endothelial cells is required for astrocytic glutamate transporter 1 (GLT-1) expression. Neurochem Int. 2020 Oct;139:104787. [Content Brief]
[3]. Elyaman W, et al. Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells. Immunity. 2012 Apr 20;36(4):623-34. [Content Brief]
[4]. Riella LV, et al. Jagged2-signaling promotes IL-6-dependent transplant rejection. Eur J Immunol. 2013 Jun;43(6):1449-58. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse Jagged 2 Antibody (HMJ2-1) Related Classifications
HY-P990206 Related Classifications
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