MOG(35-55) amide, mouse, rat

Name: MOG(35-55) amide, mouse, rat
Brand: MedChemExpress
SKU: HY-P3719
Rating: 4.5 (1 reviews)

Cat. No.: HY-P3719 Purity: 99.88%: Data Sheet
COA

SDS
Handling Instructions
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MOG (35-55) amide, mouse, rat the terminal amidation form of the 35-55 fragment of the myelin oligodendrocyte glycoprotein (MOG) immunogenic peptide (MOG (35-55) (HY-P1240)). MOG(35-55) amide, mouse, rat can be used for experimental autoimmune encephalomyelitis (EAE) modeling.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

MOG(35-55) amide, mouse, rat Chemical Structure

CAS No. : 2022956-48-3

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE MOG(35-55) amide, mouse, rat

•Scand J Immunol. 2025 Jan;101(1):e13430. [Abstract]

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CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

The expanded CD4⁺ T cells are largely specific for the myelin oligodendrocyte glycoprotein (MOG) immunogenic peptide 35-55 (MOG35-55), while clonally expanded CD8⁺ T cells were non-responsive to myelin peptides or proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MOG(35-55) amide, mouse, rat (200 μg, s.c., two immunizations on day 0 and day 7) can induce a classic experimental autoimmune encephalomyelitis (EAE) model characterized by myelin sheath damage and flaccid paralysis in ABH mice^[2].
MOG(35-55) amide, mouse, rat (200 μg, s.c., two immunizations on day 0 and day 7) is a known encephalitis-inducing epitope in C57BL/6 mice, capable of inducing chronic acute exacerbation encephalitis (EAE), but the severity and latency of the disease exhibit significant variability^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Biozzi ABH (H-2^dq1) mice (10 weeks old) were subcutaneously injected with an emulsion mixture of antigen and complete Freund's adjuvant (CFA)^[2].
Dosage:	200 μg
Administration:	S.c., two immunizations were administered on day 0 and day 7
Result:	Immunized with NF-L protein (200 μg each), significant spastic symptoms were observed, which could induce a classic EAE model characterized by myelin sheath damage and flaccid paralysis.

Animal Model:	Female 8- to 10-week-old C57BL/6 (H-2^b)^[3].
Dosage:	200 μg
Administration:	S.c., two immunizations were administered on day 0 and day 7
Result:	The incidence of induced EAE was variable (in one experiment, 5 out of 5 mice developed the disease, with an average maximum clinical score of 3.1 (infected mice only) and a group score of 3.1; in another experiment, 3 out of 5 mice developed the disease, with an average maximum clinical score of 2.8 (infected mice) and a group score of 1.7.)

Molecular Weight

2580.97

Formula

C₁₁₈H₁₇₈N₃₆O₂₈S

CAS No.

2022956-48-3

Appearance

Solid

Color

White to light yellow

Sequence

Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys-NH2

Sequence Shortening

MEVGWYRSPFSRVVHLYRNGK-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (38.75 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.3875 mL	1.9373 mL	3.8745 mL
5 mM	0.0775 mL	0.3875 mL	0.7749 mL
10 mM	0.0387 mL	0.1937 mL	0.3875 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.88%

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Data Sheet (280 KB) SDS (252 KB)

COA (253 KB) RP-HPLC (266 KB) MS (104 KB) Elemental Analysis Report (112 KB)

Handling Instructions (2659 KB)

References

[1]. Saligrama N, et al. Opposing T cell responses in experimental autoimmune encephalomyelitis. Nature. 2019 Aug;572(7770):481-487. [Content Brief]

[2]. Fabiola Puentes, et al. Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis. J Neuroinflammation. 2013 Sep 22:10:118. [Content Brief]

[3]. 2. Delarasse C, et al. Novel pathogenic epitopes of myelin oligodendrocyte glycoprotein induce experimental autoimmune encephalomyelitis in C57BL/6 mice. Immunology. 2013 Dec;140(4):456-64. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.3875 mL	1.9373 mL	3.8745 mL	9.6863 mL
	5 mM	0.0775 mL	0.3875 mL	0.7749 mL	1.9373 mL
	10 mM	0.0387 mL	0.1937 mL	0.3875 mL	0.9686 mL
	15 mM	0.0258 mL	0.1292 mL	0.2583 mL	0.6458 mL
	20 mM	0.0194 mL	0.0969 mL	0.1937 mL	0.4843 mL
	25 mM	0.0155 mL	0.0775 mL	0.1550 mL	0.3875 mL
	30 mM	0.0129 mL	0.0646 mL	0.1292 mL	0.3229 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.