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Cat. No.: HY-155251

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anti-TNBC agent-3

anti-TNBC agent-3 (compound 3g) is an apoptosis inducer with anti-cancer cell proliferation activity. anti-TNBC agent-3 inhibits tumor growth and metastasis in triple-negative breast cancer (TNBC) xenograft models.

For research use only. We do not sell to patients.

CAS No.: 2422001-25-8
Formula: C₂₉H₃₉F₂N₇O
Molecular Weight:539.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

anti-TNBC agent-3 Chemical Structure

CAS No.: 2422001-25-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

Bcl-2

All Bcl-2 Family Isoforms :

In Vitro

anti-TNBC agent-3 (compound 3g) inhibits K562 and HepG2 proliferation with IC₅₀s of 0.24 μM and 0.25 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

anti-TNBC agent-3 (compound 3g) (10 mg/kg, 20 mg/kg; ip) inhibits tumor growth and metastasis in a mouse triple-negative breast cancer (TNBC) xenograft model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2422001-25-8
Molecular Weight 539.66
Formula C₂₉H₃₉F₂N₇O
SMILES

OCCN1CCC(C2CCN(C3=NC(N(C4CCCC4)C=N5)=C5C(NCC6=CC(F)=C(F)C=C6)=N3)CC2)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang Q, et al. Synthesis and mechanism of action of new purine derivatives against triple negative breast cancer. Eur J Med Chem. 2023 Sep 7;261:115797.. . [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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