ABCA1 Antibody (YA3573)(PBS only)
(Synonyms: TGD; ABC1; CERP; ABC-1; HDLDT1; HPALP1; HDLCQTL13)ABCA1 Antibody (YA3573) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to ABCA1.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P, ICC/IF, FC
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Reactivity :
Human, Mouse, Rat, Rabbit, Monkey
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:100-1:500 | 1:200-1:1000 | 1:200-1:400 |
Product Details
ABCA1 Antibody (YA3573) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to ABCA1.
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Host Mouse
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Species ReactivityHuman, Mouse, Rat, Rabbit, Monkey
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Observed Molecular WeightObserved band size: 254 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 254 kDa
Purified recombinant fragment of human ABCA1 (AA: 2081-2261) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ABCA1 catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Thereby, participates in phospholipid transfer to apolipoproteins to form nascent high density lipoproteins/HDLs. Transports preferentially phosphatidylcholine over phosphatidylserine. May play a similar role in the efflux of intracellular cholesterol to apolipoproteins and the formation of nascent high density lipoproteins/HDLs. Translocates phospholipids from the outer face of the plasma membrane and forces it through its gateway and annulus into an elongated hydrophobic tunnel in its extracellular domain[1][2][3][4].
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Subcellular Localization
Cell membrane; Multi-pass membrane protein; Endosome
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Expression
Tissue_specificity:Widely expressed, but most abundant in macrophages
Induction:By bacterial lipopolysaccharides (LPS) . LPS regulates expression through a liver X receptor (LXR) -independent mechanism. Repressed by ZNF202 -
Subunit
Interacts with MEGF10 (PubMed:17205124). May interact with APOE1; functionally associated with APOE1 in the biogenesis of HDLs (PubMed:14754908). Interacts with ABCA8; this interaction potentiates cholesterol efflux (PubMed:28882873). Interacts with ABCA12 and NR1H2; this interaction is required for ABCA1 localization to the cell surface and is necessary for its normal activity and stability (PubMed:23931754)
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SwissProt ID
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Synonyms
TGD; ABC1; CERP; ABC-1; HDLDT1; HPALP1; HDLCQTL13
Documentation
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