ADAMTS13 Antibody (YA2002)
(Synonyms: ADAMTS13; ADAM-TS; ADAM-TS13; ADAMTS-13; ADAM-TS 13; C9orf8; TTP; VWF-CP; VWFCP)ADAMTS13 Antibody (YA2002) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ADAMTS13.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, FC
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Reactivity :
Human
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 |
Product Details
ADAMTS13 Antibody (YA2002) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ADAMTS13.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 154 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 154 kDa
A synthesized peptide derived from human ADAMTS13 aa71-125.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ADAMTS13 cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation
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Subcellular Localization
Secreted
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Expression
Tissue_specificity:Plasma. Expressed primarily in liver -
Isoforms & Post-Translational Modification
Q76LX8 has 4 isomers: Q76LX8-1: 153604 Da (predicted); Q76LX8-2: 147804 Da (predicted); Q76LX8-3: 144517 Da (predicted); Q76LX8-4: 39864 Da (predicted).
Glycosylated. O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS13. May also be C-glycosylated on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and also N-glycosylated. These other glycosylations can also facilitate secretion;The precursor is processed by a furin endopeptidase which cleaves off the pro-domain -
SwissProt ID
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Synonyms
ADAMTS13; ADAM-TS; ADAM-TS13; ADAMTS-13; ADAM-TS 13; C9orf8; TTP; VWF-CP; VWFCP
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Research Field
Signal Transduction
Documentation
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