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ADI1 Antibody (YA8505)(PBS only)

(Synonyms: APL1; ARD; Fe-ARD; HMFT1638; MTCBP1; mtnD; Ni-ARD; SIPL)

ADI1 Antibody (YA8505) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ADI1.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    ICC/IF, FC

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • ADI1 Antibody (YA8505)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
Dilution Ratio 1:100-250 1:100

Product Details

Description

ADI1 Antibody (YA8505) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ADI1.

  • Host Mouse
  • Species Reactivity
    Human
  • Calculated Molecular Weight Predicted band size: 21.3 kDa
Immunogen

Full length human recombinant protein of human ADI1 produced in HEK293T cell.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    ADI1 catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line[1][2][3].

  • Subcellular Localization

    Cytoplasm,Nucleus,Cell membrane

  • Expression


    Tissue_Specificity: Detected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle and kidney

  • Isoforms & Post-Translational Modification

    Q9BV57 has two isomers: Q9BV57-1: 21498 Da (predicted); Q9BV57-2: 20332 Da (predicted).

  • Subunit

    Monomer (By similarity)

  • SwissProt ID

    Q9BV57

  • Synonyms

    APL1; ARD; Fe-ARD; HMFT1638; MTCBP1; mtnD; Ni-ARD; SIPL

ADI1 Antibody (YA8505)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • ADI1 Antibody (YA8505)(PBS only) Product Image
    1/16
  • ADI1 Antibody (YA8505)(PBS only) Product Image