ANAPC2 (Apc2) Antibody (YA8465)
(Synonyms: APC2)ANAPC2 (Apc2) Antibody (YA8465) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to ANAPC2 (Apc2).
-
Host:
Mouse
-
Isotype:
IgG2a
-
Application:
IHC-P, ICC/IF, FC
-
Reactivity :
Human, Rat, Monkey, Mouse
-
Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
|
|---|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100-250 | 1:100 |
Product Details
ANAPC2 (Apc2) Antibody (YA8465) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to ANAPC2 (Apc2).
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman, Rat, Monkey, Mouse
-
Calculated Molecular Weight Predicted band size: 93.6 kDa
Full length human recombinant protein of human ANAPC2 produced in HEk293 cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
-
Appearance
Liquid
-
Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
ANAPC2 is a Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation[1][2][3].
-
Isoforms & Post-Translational Modification
Q9UJX6 has two isomers: Q9UJX6-1: 93828 Da (predicted); Q9UJX6-2: 93469 Da (predicted).
-
Subunit
The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1
-
SwissProt ID
-
Synonyms
APC2
Documentation
Powered by Bioz
