ANP32E Antibody
(Synonyms: Acidic leucine-rich nuclear phosphoprotein 32 family member E, LANP-like protein, LANP-L, ANP32E)ANP32E Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ANP32E.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:10-50 |
Product Details
ANP32E Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ANP32E.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 26 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 30 kDa
Synthetic peptide corresponding to the N-terminal region of human ANP32E.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ANP32E is a Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis[1].
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Subcellular Localization
Cytoplasm; Nucleus
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Expression
Tissue_Specificity: Expressed in peripheral blood leukocytes, colon, small intestine, prostate, thymus, spleen, skeletal muscle, liver and kidney. -
Isoforms & Post-Translational Modification
ANP32E has 3 isoforms, Q9BTT0-1: amino acid length is 268, molecular weight is 30692 Da (predicted); Q9BTT0-2: amino acid length is 227, molecular weight is 26321 Da (predicted); Q9BTT0-3: amino acid length is 220, molecular weight is 25125 Da (predicted).Phosphorylated. The phosphorylation is nuclear localization signal (NLS)-dependent (By similarity)
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Subunit
Interacts with the importin alpha KPNA1 and KPNA2 (By similarity).
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SwissProt ID
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Synonyms
Acidic leucine-rich nuclear phosphoprotein 32 family member E, LANP-like protein, LANP-L, ANP32E
Documentation
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