ATP6V1B1 Antibody (YA7871)(PBS only)
(Synonyms: ATP6B1; RTA1B; VATB; VMA2; VPP3)ATP6V1B1 Antibody (YA7871) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ATP6V1B1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ICC/IF, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100-250 | 1:100 |
Product Details
ATP6V1B1 Antibody (YA7871) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ATP6V1B1.
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Host Mouse
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 56.7 kDa
Full length human recombinant protein of human ATP6V1B1 produced in HEK293T cell.
Affinity purified
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ATP6V1B1 is a Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Essential for the proper assembly and activity of V-ATPase. In renal intercalated cells, mediates secretion of protons (H+) into the urine thereby ensuring correct urinary acidification. Required for optimal olfactory function by mediating the acidification of the nasal olfactory epithelium[1][2].
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Subcellular Localization
Apical cell membrane,Basolateral cell membrane
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Expression
Tissue_Specificity: Kidney; localizes to early distal nephron, encompassing thick ascending limbs and distal convoluted tubules (at protein level) (PubMed:16769747, PubMed:29993276). Expressed in the cochlea and endolymphatic sac (PubMed:9916796) -
Isoforms & Post-Translational Modification
P15313: 513 amino acids, molecular weight 56833 Da.
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Subunit
V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity)
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SwissProt ID
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Synonyms
ATP6B1; RTA1B; VATB; VMA2; VPP3
Documentation
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