CBWD1 Antibody (YA8437)
(Synonyms: COBP)CBWD1 Antibody (YA8437) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CBWD1.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
IHC-P, FC
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Reactivity :
Human, Dog, Rat, Monkey
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100 |
Product Details
CBWD1 Antibody (YA8437) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CBWD1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Dog, Rat, Monkey
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Calculated Molecular Weight Predicted band size: 43.9 kDa
Full length human recombinant protein of human CBWD1 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Solution
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CBWD1 is a Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1A to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1
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Subcellular Localization
Nucleus
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Expression
Tissue_Specificity: Ubiquitously expressed. Up-regulated in cultured astrocytes treated with dopamine
Induction: Down-regulated in response to zinc: repressed by ZNF658 in response to zinc by binding to the zinc transcriptional regulatory element (ZTRE) (5'-C[AC]C[TAG]CC[TC]-N(0-50)-[GA]G[ATC]G[TG]G-3') found in the promoter region of CBWD1 (PubMed:22902622, PubMed:25582195). Increased expression in response to dopamine treatment (PubMed:11489251) -
Isoforms & Post-Translational Modification
Q9BRT8 has four isomers: Q9BRT8-1: 44068 Da (predicted); Q9BRT8-2: 40420 Da (predicted); Q9BRT8-3: 42015 Da (predicted); Q9BRT8-4: 12172 Da (predicted).
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SwissProt ID
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Synonyms
COBP
Documentation
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