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  5. CD209 Antibody (YA4510)

CD209 Antibody (YA4510) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD209.

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容量 価格（税別） 在庫状況 数量
20 μL $167 Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL $252 Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL $408 Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   お問い合わせ  
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* アイテムを追加する前、数量をご選択ください

Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 説明

製品説明

CD209 Antibody (YA4510) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD209.
Host

Mouse
Clonality

Monoclonal
分子量
Predicted band size: 46 kDa;
Observed band size: 50 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

Purified recombinant fragment of human CD209 (AA: extra 270-404) expressed in E. Coli.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:2000
FC
FC: Flow Cytometry
1:200-1:400
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
1:10000
純度 affinity purified. Conjugation Non-conjugated
Modification Unmodified Isotype IgG1
Appearance

Solution
Formulation

Supplied in PBS with 0.05% sodium azide
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
輸送条件

Shipping with blue ice.
Background
Function：Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response; On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells; (Microbial infection) Acts as an attachment receptor for HIV-1 and HIV-2; (Microbial infection) Acts as an attachment receptor for Ebolavirus; (Microbial infection) Acts as an attachment receptor for Cytomegalovirus; (Microbial infection) Acts as an attachment receptor for HCV; (Microbial infection) Acts as an attachment receptor for Dengue virus; (Microbial infection) Acts as an attachment receptor for Measles virus; (Microbial infection) Acts as an attachment receptor for Herpes simplex virus 1; (Microbial infection) Acts as an attachment receptor for Influenzavirus A; (Microbial infection) Acts as an attachment receptor for SARS-CoV; (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus; (Microbial infection) Acts as an attachment receptor for Lassa virus (PubMed:23966408). Acts as an attachment receptor for Marburg virusn; (Microbial infection) Acts as an attachment receptor for Respiratory syncytial virus; (Microbial infection) Acts as an attachment receptor for Rift valley fever virus and uukuniemi virus; (Microbial infection) Acts as an attachment receptor for West-nile virus; (Microbial infection) Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of bacterial pathogen antigens, including Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA (PubMed:16379498). Recognition of M.tuberculosis by dendritic cells occurs partially via this molecule (PubMed:16092920, PubMed:21203928)
Subcellular Localization：Cell membrane; Single-pass type II membrane protein; Cell membrane; Single-pass type II membrane protein; Cell membrane; Single-pass type II membrane protein; Cell membrane; Single-pass type II membrane protein; Cell membrane; Single-pass type II membrane protein; Secreted; Secreted; Secreted; Secreted; Secreted; Secreted; Secreted
Expression：
Tissue_specificity:It is mainly expressed in dendritic cells and the tissues in which dendritic cells reside. It is also found in placental macrophages, placental vascular endothelial cells, peripheral blood monocytes, and THP-1 monocytes.
Isoforms & Post-Translational Modification：Q9NNX6 has 12 isomers: Q9NNX6-1: 45775 Da (predicted); Q9NNX6-2: 45031 Da (predicted); Q9NNX6-3: 35236 Da (predicted); Q9NNX6-4: 18646 Da (predicted); Q9NNX6-5: 45571 Da (predicted); Q9NNX6-6: 43330 Da (predicted); Q9NNX6-7: 41009 Da (predicted); Q9NNX6-8: 30427 Da (predicted); Q9NNX6-9: 4046 Da (predicted); Q9NNX6-10: 43126 Da (predicted); Q9NNX6-11: 37844 Da (predicted); Q9NNX6-12: 33874 Da (predicted).
Subunit：Homotetramer. Interacts with C1QBP; the interaction is indicative for a C1q:C1QBP:CD209 signaling complex. Interacts with ICAM2 and ICAM3 by binding to mannose-like carbohydrates. Interacts (via C-type lectin domain) with CEACAM1 (via Lewis X moieties); this interaction is regulated by the glycosylation pattern of CEACAM1 on cell types and regulates contact between dendritic cells and neutrophils (PubMed:16246332)
Synonyms
CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1
ドキュメンテーション
User Guide for Antibodies (1077 KB)

CD209 Antibody (YA4510) 関連分類

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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製品名:
CD209 Antibody (YA4510)
製品番号:
HY-P84813
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