LIGHT/TNFSF14 Antibody (YA3540)
(Synonyms: TNFSF14; LTg; HVEML; LIGHT)LIGHT/TNFSF14 Antibody (YA3540) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to LIGHT/TNFSF14.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
WB, IHC-P, FC, ELISA
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
LIGHT/TNFSF14 Antibody (YA3540) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to LIGHT/TNFSF14.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 26 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 26 kDa
Purified recombinant fragment of human CD258 (AA: extra 59-240) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
LIGHT/TNFSF14 is a Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Acts as a ligand for TNFRSF14/HVEM. Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production[1][2].
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Subcellular Localization
Cell membrane; Single-pass type II membrane protein; Secreted; Cytoplasm
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Expression
Tissue_specificity:It is primarily expressed in the spleen, but also found in brain tissue. Expression is weaker in peripheral lymphoid tissues, as well as in the heart, placenta, liver, lungs, appendix, and kidneys. It has not been observed in fetal tissues, endocrine glands, or non-hematopoietic tumor cell lines.
Induction:Up-regulated after T-cell activation -
Isoforms & Post-Translational Modification
O43557 has 2 isomers: O43557-1: 26350 Da (predicted); O43557-2: 22395 Da (predicted).
N-glycosylated;The soluble form of isoform 1 derives from the membrane form by proteolytic processing -
Subunit
Homotrimer. Interacts with TNFRSF14
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SwissProt ID
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Synonyms
TNFSF14; LTg; HVEML; LIGHT
Documentation
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