CD69 Antibody (YA4201)(PBS only)
(Synonyms: CLEC2C; CD69)CD69 Antibody (YA4201) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD69.
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
CD69 Antibody (YA4201) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD69.
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Host Mouse
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 20-30 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 23 kDa
Purified recombinant fragment of human CD69 aa 69-199.
affinity purified.
Non-conjugated
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD69 is a transmembrane protein primarily expressed on mucosa-resident T cells, playing a crucial role in immune cell homeostasis. Following activation by various stimuli-such as antigen recognition or cytokine signaling-CD69 is rapidly expressed on the surface of platelets, T lymphocytes, and NK cells, where it activates distinct signaling pathways across different cell types. CD69 negatively regulates Th17 cell differentiation through a carbohydrate-dependent interaction with galectin-1 (LGALS1) present on immature dendritic cells. It also acts via the S100A8/S100A9 complex on peripheral blood monocytes to promote the conversion of naive CD4+ T cells into regulatory T cells. Mechanistically, it specifically recognizes Pseudomonas aeruginosa, promoting ERK1 activation and the subsequent secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) and other inflammatory cytokines.
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Subcellular Localization
Cell membrane; Single-pass type II membrane protein
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Expression
Tissue_specificity:It is expressed on the surface of activated T cells, B cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells, and platelets.
Induction:By antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes. By interaction of IL-2 with the p75 IL-2R on the surface of NK cells -
Subunit
Homodimer; disulfide-linked. Interacts with S100A8 and S100A9. Interacts with galactin-1/LGALS1. Interacts with S1PR1; this interaction mediates S1PR1 degradation
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SwissProt ID
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Synonyms
CLEC2C; CD69
Documentation
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