CD93 Antibody (YA6987)
(Synonyms: C1q receptor 1 antibody; C1q/MBL/SPA receptor antibody; C1qR antibody; C1qR(p) antibody; C1qr1 antibody; C1QR1_HUMAN antibody; C1qRp antibody; CD93 antibody; CD93 antigen antibody; CD93 molecule antibody)CD93 Antibody (YA6987) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD93.
-
Host:
Mouse
-
Isotype:
IgG1
-
Application:
WB, ICC/IF, IHC-P, FC
-
Reactivity :
Human
-
Formulation:
Supplied in in PBS with 0.05% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
FC
FC: Flow Cytometry
|
|---|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:200 | 1:50-1:200 | 1:100-1:200 |
Product Details
CD93 Antibody (YA6987) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD93.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman
-
Observed Molecular WeightObserved band size: 69 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 69 kDa
Purified recombinant fragment of human CD93 (AA: 474-535) expressed in E. Coli.
Endogenous
Protein A affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in in PBS with 0.05% sodium azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
CD93 cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis. Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration. Participates in angiogenesis also by acting as a receptor for the ECM pan-endothelial glycoprotein multimerin-2/MMRN2 and IGFBP7 ligands. Both ligands play a non-redundant role in CD93-mediated endothelial cell function. Acts as a key regulator of endothelial barrier function through modulating VEGFR2 function[1][2][3][4][5][6].
-
Subcellular Localization
Cell membrane
-
Expression
Tissue_Specificity: Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin -
Isoforms & Post-Translational Modification
Q9NPY3: 652 amino acids, molecular weight 68560 Da.
-
Subunit
Homodimer (PubMed:36265539)
-
SwissProt ID
-
Synonyms
C1q receptor 1 antibody; C1q/MBL/SPA receptor antibody; C1qR antibody; C1qR(p) antibody; C1qr1 antibody; C1QR1_HUMAN antibody; C1qRp antibody; CD93 antibody; CD93 antigen antibody; CD93 molecule antibody
Documentation
Powered by Bioz
