CDX1+CDX2+CDX4 Antibody (YA5488)
(Synonyms: Caudal type homeo box 2 antibody; Caudal type homeo box transcription factor 2 antibody; Caudal type homeobox 2 antibody; Caudal type homeobox protein 2 antibody; Caudal type homeobox transcription factor 2 antibody; Caudal-type homeobox protein 2 antibody; CDX 2 antibody; CDX 3 antibody; CDX-3 antibody; Cdx2 antibody; CDX2/AS antibody; CDX2_HUMAN antibody; CDX3 antibody; Homeobox protein CDX 2 antibody; Homeobox protein CDX-2 antibody; )CDX1+CDX2+CDX4 Antibody (YA5488) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CDX1+CDX2+CDX4.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P, ICC/IF, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:200-1000 | 1:100-500 | 1:1000-5000 |
Product Details
CDX1+CDX2+CDX4 Antibody (YA5488) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CDX1+CDX2+CDX4.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
Synthesized peptide derived from human CDX-2 AA range: 150-265
Protein G
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CDX1+CDX2+CDX4 is a P47902: Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 promoter in colorectal cancer (CRC) cells. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA
Q99626: Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium. Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription. Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription. Binds to and activates transcription of LPH. Activates transcription of CLDN2 and intestinal mucin MUC2. Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA
[1][2]. -
Subcellular Localization
P47902: Nucleus
Q99626: Nucleus
O14627: Nucleus -
Expression
Tissue_specificity: P47902: Intestinal epithelium
Q99626: Detected in small intestine, colon and pancreas -
Isoforms & Post-Translational Modification
P47902 has 2 isomers: P47902-1: 28138 Da (predicted); P47902-2: 14661 Da (predicted).
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Subunit
Q99626: Can bind DNA as a monomer or homodimer
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Synonyms
Caudal type homeo box 2 antibody; Caudal type homeo box transcription factor 2 antibody; Caudal type homeobox 2 antibody; Caudal type homeobox protein 2 antibody; Caudal type homeobox transcription factor 2 antibody; Caudal-type homeobox protein 2 antibody; CDX 2 antibody; CDX 3 antibody; CDX-3 antibody; Cdx2 antibody; CDX2/AS antibody; CDX2_HUMAN antibody; CDX3 antibody; Homeobox protein CDX 2 antibody; Homeobox protein CDX-2 antibody;
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