CIRBP Antibody (YA4257)
(Synonyms: CIRP)CIRBP Antibody (YA4257) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CIRBP.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:10000 |
Product Details
CIRBP Antibody (YA4257) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CIRBP.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 19 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 19 kDa
Purified recombinant fragment of human CIRBP (AA: 1-90) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CIRBP is a Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor. Promotes assembly of stress granules (SGs), when overexpressed
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Subcellular Localization
Nucleus, nucleoplasm; Cytoplasm
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Expression
Tissue_specificity:general expression
Induction:By cold stress in response to DNA damage induced by UV irradiation or UV mimetic agents. Up-regulated by hypoxia -
Isoforms & Post-Translational Modification
Q14011 has 3 isomers: Q14011-1: 18648 Da (predicted); Q14011-2: 28359 Da (predicted); Q14011-3: 26130 Da (predicted).
Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs (By similarity);Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3'-UTR transcript upon exposure to UV radiation -
Subunit
Interacts with EIF4G1. Associates with ribosomes
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SwissProt ID
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Synonyms
CIRP
Documentation
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