CIRBP - cold inducible RNA binding protein Gene

Also Known as CIRP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1153

About CIRBP

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,269,332-1,274,880 (from NCBI)

This gene has 46 transcripts (splice variants), 163 orthologues and 36 paralogues. Ubiquitous expression in ovary (RPKM 151.3), endometrium (RPKM 107.4) and 25 other tissues.

Summary

Enables mRNA 3'-UTR binding activity and small ribosomal subunit rRNA binding activity. Involved in mRNA stabilization; positive regulation of translation; and response to UV. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CIRBP Products (3)

mRNA	Protein	Name
NM_001280.3	NP_001271.1	cold-inducible RNA-binding protein isoform 1
NM_001300815.2	NP_001287744.1	cold-inducible RNA-binding protein isoform 2
NM_001300829.2	NP_001287758.1	cold-inducible RNA-binding protein isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	11574538	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables small ribosomal subunit rRNA binding	IDA IDA: Inferred from direct assay	11574538	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA stabilization	IDA IDA: Inferred from direct assay	11574538	GOA
involved in positive regulation of translation	IDA IDA: Inferred from direct assay	11574538	GOA
involved in response to UV	IDA IDA: Inferred from direct assay	11574538	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11574538	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11574538	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CIRBP Protein Structure

RRM_1

0
100
172 a.a.

Protein Preferred Names	Protein Names
cold-inducible RNA-binding protein	A18 hnRNP

CIRBP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CIRBP	Q14011	HNRNPK	Homo sapiens	P61978	Y2H	22365833
Intra	CIRBP	Q14011	HNRNPK	Homo sapiens	P61978	Y2H Prey Pooling	25416956
Intra	CIRBP	Q14011	HNRNPK	Homo sapiens	P61978	Y2H Array	29892012
Intra	CIRBP	Q14011	HNRNPK	Homo sapiens	P61978	Y2H	21516116
Intra	CIRBP	Q14011	SRSF3	Homo sapiens	P84103	Y2H Array	32296183
Intra	CIRBP	Q14011	SRSF3	Homo sapiens	P84103	Y2H Prey Pooling	32296183
Intra	CIRBP	Q14011	SNRPA	Homo sapiens	P09012	Y2H Array	31515488
Intra	CIRBP	Q14011	HNRNPK	Homo sapiens	P61978-2	Y2H Prey Pooling	32296183
Intra	CIRBP	Q14011	HNRNPK	Homo sapiens	P61978-2	Y2H Array	32296183
Intra	CIRBP	Q14011	LNX1	Homo sapiens	Q8TBB1	Y2H Array	25416956
Intra	CIRBP	Q14011	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	25416956
Intra	CIRBP	Q14011	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Array	25416956
Intra	CIRBP	Q14011	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Array	31515488
Intra	CIRBP	Q14011	RBMX	Homo sapiens	P38159	Y2H Array	25416956
Intra	CIRBP	Q14011	RBMX	Homo sapiens	P38159	Y2H Pooling	16189514
Intra	CIRBP	Q14011	RBMX	Homo sapiens	P38159	Y2H Prey Pooling	25416956
Intra	CIRBP	Q14011	RBMY1A1	Homo sapiens	P0DJD3	Y2H Prey Pooling	25416956
Intra	CIRBP	Q14011	RBMY1A1	Homo sapiens	P0DJD3	Validated Y2H	25416956
Intra	CIRBP	Q14011	RBMY1F	Homo sapiens	Q15415	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CIRBP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76261	CIRBP Protein, Human (His)	Q14011-1 (M1-E172)	≥ 90%, as determined by reducing SDS-PAGE.

CIRBP Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82761	CIRBP Antibody (YA2506)	WB, IHC-P, IP	Human
HY-P82761A	CIRBP Antibody (YA2506)(PBS only)	WB, IHC-P, IP	Human
HY-P84560	CIRBP Antibody (YA4257)	WB, IHC-P, ELISA	Human
HY-P84560A	CIRBP Antibody (YA4257)(PBS only)	WB, IHC-P, ELISA	Human
HY-P86112	CIRBP Antibody (YA5804)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86632	CIRBP Antibody (YA6324)	WB, IHC-P, ICC/IF, IP, ELISA	Human

Related Diseases

Diseases	Alias
Cryptorchidism, Unilateral Or Bilateral	Cryptorchidism Undescended Testicle Undescended Testis Cryptorchism Undescended Testicles CRYPTO Impaired Testicular Descent Cryptosporidiosis Retained Testis Unilateral Cryptorchidism Unilateral Undescended Testis Nondescent Unilateral Testicle Unilateral Cryptorchism Ectopic Testis, Unilateral Bilateral Cryptorchidism Bilateral Cryptorchism Bilateral Nondescent Testicle Bilateral Undescended Testes Bilateral Ectopic Testes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125972	zr17-2	Activator	98.01%	Unkown
HY-RS02721	CIRBP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-180496	(S)-NSC 121182		/	Unkown
HY-RS17760	Cirbp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24227	Cirbp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CIRBP	RGD	RGD:620756
Mus musculus	CIRBP	MGD	MGI:893588
Macaca mulatta	CIRBP	VGNC	VGNC:81371
Felis catus	CIRBP	VGNC	VGNC:60908
Bos taurus	CIRBP	VGNC	VGNC:52752
Canis familiaris	CIRBP	VGNC	VGNC:54590
Others	CIRBP	NCBI