CLIP170 Antibody (YA2810)(PBS only)
(Synonyms: RSN; CLIP; CYLN1; CLIP170; CLIP-170)CLIP170 Antibody (YA2810) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CLIP170.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-F, IHC-P, ICC/IF, IP
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IP
IP: Immunoprecipitation
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|---|---|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 | 1:50-1:100 | 1:50-1:200 | 1:20 |
Product Details
CLIP170 Antibody (YA2810) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CLIP170.
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Host Rabbit
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 170 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 162 kDa
A synthetic peptide of human CLIP170
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CLIP170 binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking
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Subcellular Localization
Cytoplasm; Cytoplasm, cytoskeleton; Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side; Cell projection, ruffle
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Expression
Tissue_specificity:Detected in dendritic cells (at protein level) . Highly expressed in the Reed-Sternberg cells of Hodgkin disease -
Isoforms & Post-Translational Modification
P30622 has 3 isomers: P30622-3: 162246 Da (predicted); P30622-1: 160990 Da (predicted); P30622-2: 156781 Da (predicted).
Phosphorylated. Phosphorylation induces conformational changes by increasing the affinity of the N-terminus for C-terminus, resulting in inhibition of its function thus decreasing its binding to microtubules and DCTN1. Exhibits a folded, autoinhibited conformation when phosphorylated and an open conformation when dephosphorylated with increased binding affinity to microtubules and DCTN1. Phosphorylation regulates its recruitment to tyrosinated microtubules and the recruitment of vesicular cargo to microtubules in neurons (By similarity). Phosphorylation by MTOR may positively regulate CLIP1 association with microtubules (PubMed:12231510) -
Subunit
Interacts with MTOR; phosphorylates and regulates CLIP1 (PubMed:12231510). Interacts (via CAP-Gly domains) with tubulin (PubMed:17563362, PubMed:17889670). Interacts with SLAIN2 (PubMed:21646404).
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SwissProt ID
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Synonyms
RSN; CLIP; CYLN1; CLIP170; CLIP-170
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Research Field
Cell Biology
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