CLIP1 - CAP-Gly domain containing linker protein 1 Gene

Also Known as RSN; CLIP; CYLN1; CLIP170; CLIP-170

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6249

About CLIP1

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:122,271,469-122,422,956 (from NCBI)

This gene has 20 transcripts (splice variants), 318 orthologues, 4 paralogues and is associated with 79 phenotypes. Ubiquitous expression in thyroid (RPKM 36.8), esophagus (RPKM 33.7) and 25 other tissues.

Summary

The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

CLIP1 Products (4)

mRNA Protein Name
NM_001247997.2 NP_001234926.1 CAP-Gly domain-containing linker protein 1 isoform c
NM_001389291.1 NP_001376220.1 CAP-Gly domain-containing linker protein 1 isoform d
NM_002956.3 NP_002947.1 CAP-Gly domain-containing linker protein 1 isoform a
NM_198240.3 NP_937883.1 CAP-Gly domain-containing linker protein 1 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
17828275 GOA
enables microtubule binding IDA
IDA: Inferred from direct assay
17889670 GOA
enables microtubule plus-end binding IDA
IDA: Inferred from direct assay
12433698 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11940666 GOA
enables tubulin binding IDA
IDA: Inferred from direct assay
17889670 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
17828275 GOA
Biological Process GO Annotation Evidence References Source
involved in microtubule bundle formation IMP
IMP: Inferred from mutant phenotype
17889670 GOA
involved in positive regulation of microtubule polymerization IMP
IMP: Inferred from mutant phenotype
15262990 GOA
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
colocalizes with macropinosome IDA
IDA: Inferred from direct assay
12433698 GOA
located in microtubule IMP
IMP: Inferred from mutant phenotype
19004523 GOA
located in microtubule cytoskeleton IMP
IMP: Inferred from mutant phenotype
17889670 GOA
colocalizes with microtubule plus-end IDA
IDA: Inferred from direct assay
12433698 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLIP1 Protein Structure

CAP_GLY

CAP_GLY: CAP-Gly domain (60 - 124)

CAP_GLY

CAP_GLY: CAP-Gly domain (214 - 278)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1438 a.a.
Protein Preferred Names Protein Names

CAP-Gly domain-containing linker protein 1

  • cytoplasmic linker protein 1

CLIP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CLIP1 P30622 MAPRE1 Homo sapiens Q15691
Chromatography
16455083
Intra
CLIP1 P30622 REL Homo sapiens Q04864-2
Validated Y2H
32296183
Intra
CLIP1 P30622 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
CLIP1 P30622 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
CLIP1 P30622 TUBA4A Homo sapiens P68366
Pull Down
16455083
Cross: Cross-species interaction Intra: Intraspecies interaction

CLIP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83065 CLIP170 Antibody (YA2810) WB, IHC-P, ICC/IF Human
HY-P83065A CLIP170 Antibody (YA2810)(PBS only) WB, IHC-F, IHC-P, ICC/IF, IP Human

Related Diseases

Diseases Alias
Autosomal Recessive Non-Syndromic Intellectual Disability

  • Ar-Nsid

  • Ns-Arid
Perry Syndrome

  • Parkinsonism With Alveolar Hypoventilation And Mental Depression

  • PERRYS
Neuronopathy, Distal Hereditary Motor, Type Viib

  • HMN7B

  • Hmn Viib

  • Dhmn7b

  • Neuropathy, Distal Hereditary Motor, Type Viib

  • Distal Hereditary Motor Neuronopathy Type 7b

  • Distal Hereditary Motor Neuropathy Type Viib

  • Neuronopathy, Distal Hereditary Motor, Type 7b

  • Neuropathy, Distal Hereditary Motor, With Vocal Cord Paralysis, Type Viib

  • Lower Motor Neuron Disease, Dynactin Type

  • Distal Spinal Muscular Atrophy With Vocal Cord Paralysis Type 7b

  • Harper-Young Myopathy

  • Neuronopathy, Distal Hereditary Motor, 7b

  • Distal Hereditary Motor Neuropathy With Vocal Cord Paralysis Type Viib

  • Lower Motor Neuron Disease Dynactin Type

  • Plmnd

  • Progressive Lower Motor Neuron Disease

  • Neuropathy, Motor, Distal, Hereditary, Type Viib
Distal Hereditary Motor Neuronopathy Type 7

  • Dhmn7

  • Dhmnvpy

  • Distal Spinal Muscular Atrophy With Vocal Cord Paralysis
Lissencephaly

  • Pachygyria

  • Broad Gyri Of Cerebrum

  • Large Gyri Of Cerebrum

  • Macrogyria
Alacrima, Achalasia, And Mental Retardation Syndrome

  • AAMR

  • Alacrima, Achalasia, And Intellectual Disability Syndrome

  • Alacrima, Achalasia, And Impaired Intellectual Development Syndrome

  • Intellectual Disability
Lissencephaly 1

  • LIS1

  • Classic Lissencephaly

  • Ils

  • Subcortical Laminar Heterotopia

  • Lissencephaly Due To Lis1 Mutation

  • Lissencephaly Sequence, Isolated

  • Lissencephaly, Classic

  • Pafah1b1-Related Lissencephaly

  • Classical Lissencephaly

  • Lissencephaly Type 1

  • Lissencephaly-1

  • Subcortical Band Heterotopia

  • Double Cortex

  • Lissencephaly Classic

  • Lissencephaly Sequence Isolated

  • Isolated Lissencephaly Sequence

  • Type 1 Lissencephaly

  • Lissencephaly Syndrome Type 1

  • SBH

  • Sclh

  • Lissencephaly, Type 1

  • Type I Lissencephaly
Congenital Nervous System Abnormality

  • Congenital Neurologic Anomaly

  • Congenital Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-171155 CLIP1-LTK fusion protein regulator-1 Inhibitor / Unkown
HY-RS02810 CLIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20887 Clip1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27404 Clip1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CLIP1 RGD RGD:67404
Canis familiaris CLIP1 VGNC VGNC:39343
Felis catus CLIP1 VGNC VGNC:60961
Bos taurus CLIP1 VGNC VGNC:27444
Macaca mulatta CLIP1 VGNC VGNC:71166
Mus musculus CLIP1 MGD MGI:1928401
Others CLIP1 NCBI