Dishevelled 2 Antibody (YA9702)
(Synonyms: Dishevelled 2 (homologous to Drosophila dsh), Dishevelled dsh homolog 2, dishevelled segment polarity protein 2, Dishevelled-2, Dishevelled2, DSH homolog 2, DVL 2, Dvl2, DVL2_HUMAN, Segment polarity protein dishevelled homolog DVL 2)Dishevelled 2 Antibody (YA9702) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to Dishevelled 2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF, IHC-P, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|---|---|
| Dilution Ratio | 1:2000 | 1:100 | 1:50-200 | 1:1000 |
Product Details
Dishevelled 2 Antibody (YA9702) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to Dishevelled 2.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 79 kDa;
Recombinant protein of human Dishevelled 2 (aa 550-700).
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Dishevelled 2 plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling[1].
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Subcellular Localization
Cell membrane; Cytoplasm, cytosol; Cytoplasmic vesicle; Nucleus
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Isoforms & Post-Translational Modification
Dishevelled 2 has an amino acid length of 736, molecular weight is 78948 Da.
Phosphorylated by CSNK1D. WNT3A induces DVL2 phosphorylation by CSNK1E and MARK kinases. -
Subunit
Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2.
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SwissProt ID
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Synonyms
Dishevelled 2 (homologous to Drosophila dsh), Dishevelled dsh homolog 2, dishevelled segment polarity protein 2, Dishevelled-2, Dishevelled2, DSH homolog 2, DVL 2, Dvl2, DVL2_HUMAN, Segment polarity protein dishevelled homolog DVL 2
Documentation
References
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