DR4/TNFRSF10A Antibody (YA7092)(PBS only)
(Synonyms: CD261, APO2, DR4, TRAILR1, TNFRSF10A, Tumor necrosis factor receptor superfamily member 10A, Death receptor 4, TNF-related apoptosis-inducing ligand receptor 1, TRAIL receptor 1, TRAIL-R1)DR4/TNFRSF10A Antibody (YA7092) is a Rabbit-derived and non-conjugated IgG Recombinant monoclonal antibody, targeting to DR4/TNFRSF10A.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, ICC/IF, FC
-
Reactivity :
Human
-
Formulation:
Supplied in PBS, pH 7.4.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
|
|---|---|---|---|
| Dilution Ratio | 1:5000 | 1:100-200 | 1:1000 |
Product Details
DR4/TNFRSF10A Antibody (YA7092) is a Rabbit-derived and non-conjugated IgG Recombinant monoclonal antibody, targeting to DR4/TNFRSF10A.
-
Host Rabbit
-
Clonality Recombinant
-
Species ReactivityHuman
-
Calculated Molecular Weight Predicted band size: 50kDa;
Purified recombinant fragment of human TNFRSF10A (AA: extra 260-470) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in PBS, pH 7.4.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
DR4/TNFRSF10A receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B[1][2][3][4].
-
Subcellular Localization
Cell membrane,Membrane raft,Cytoplasm, cytosol
-
Expression
Tissue_Specificity: Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells -
Isoforms & Post-Translational Modification
O00220: 468 amino acids, molecular weight 50089 Da.
-
Subunit
Monomer (PubMed:26457518)
-
SwissProt ID
-
Synonyms
CD261, APO2, DR4, TRAILR1, TNFRSF10A, Tumor necrosis factor receptor superfamily member 10A, Death receptor 4, TNF-related apoptosis-inducing ligand receptor 1, TRAIL receptor 1, TRAIL-R1
Documentation
Powered by Bioz
