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EIF5A2 Antibody (YA8484)(PBS only)

(Synonyms: EIF-5A2; eIF5AII)

EIF5A2 Antibody (YA8484) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to EIF5A2.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    WB, IHC-P, ICC/IF, FC

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • EIF5A2 Antibody (YA8484)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
Dilution Ratio 1:2000 1:150-500 1:100-250 1:100

Product Details

Description

EIF5A2 Antibody (YA8484) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to EIF5A2.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 16.6 kDa
Immunogen

Full length human recombinant protein of human EIF5A2 produced in HEK293T cell.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS, pH 7.4.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    EIF5A2 is a Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step. Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity[1].

  • Subcellular Localization

    Cytoplasm,Nucleus,Endoplasmic reticulum membrane

  • Expression


    Tissue_Specificity: Expressed in ovarian and colorectal cancer cell lines (at protein level). Highly expressed in testis. Overexpressed in some cancer cells

  • Isoforms & Post-Translational Modification

    Q9GZV4: 153 amino acids, molecular weight 16793 Da.

  • Subunit

    Binds to 80S ribosomes (By similarity)

  • SwissProt ID

    Q9GZV4

  • Synonyms

    EIF-5A2; eIF5AII

EIF5A2 Antibody (YA8484)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • EIF5A2 Antibody (YA8484)(PBS only) Product Image
    1/16
  • EIF5A2 Antibody (YA8484)(PBS only) Product Image