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Cat. No.: HY-P84543A

GAB1 Antibody (YA4240)(PBS only)

Name: GAB1 Antibody (YA4240)(PBS only)
Brand: MedChemExpress
SKU: HY-P84543A
Availability: PreOrder

(Synonyms: GRB2-associated-binding protein 1, GRB2-associated binder 1, Growth factor receptor bound protein 2-associated protein 1, GAB1)

GAB1 Antibody (YA4240) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GAB1.

For research use only. We do not sell to patients.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	IHC-P IHC-P: Immunohistochemistry-Paraffin	FC FC: Flow Cytometry	ELISA ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio	1:500-1:2000	1:200-1:1000	1:200-1:400	1:10000

Description

GAB1 Antibody (YA4240) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GAB1.

Host Mouse
Species Reactivity
Human
Observed Molecular Weight

Observed band size: 110 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 77 kDa

Immunogen

Purified recombinant fragment of human GAB1 aa 661-724.

Purification

affinity purified.

Conjugation

Non-conjugated

Isotype

IgG1

Appearance

Solution
Formulation

Supplied in PBS, pH 7.4.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

GAB1 is an Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway^[1].
Isoforms & Post-Translational Modification

Q13480 has 2 isomers: Q13480-1: 76616 Da (predicted); Q13480-2: 80005 Da (predicted).
Phosphorylated in response to FGFR1 activation. Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Phosphorylated on tyrosine residues by HCK upon IL6 signaling
Subunit

Forms a tripartite complex containing GAB1, METTL13 and SPRY2 (PubMed:29408807). Within the complex interacts with METTL13 (PubMed:29408807).
SwissProt ID

Q13480
Gene ID

2549 [NCBI]
Synonyms

GRB2-associated-binding protein 1, GRB2-associated binder 1, Growth factor receptor bound protein 2-associated protein 1, GAB1