GADD45A Antibody (YA5298)
(Synonyms: DDIT 1; DDIT-1; DDIT1; DNA damage inducible transcript 1; DNA damage-inducible transcript 1 protein; GA45A_HUMAN; GADD45; GADD45A; Growth arrest and DNA damage inducible 45 alpha; Growth arrest and DNA damage inducible alpha; Growth arrest and DNA damage-inducible protein GADD45 alpha.)GADD45A Antibody (YA5298) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to GADD45A.
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Host:
Mouse
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Application:
WB
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Reactivity :
Transfected
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:1000 |
Product Details
GADD45A Antibody (YA5298) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to GADD45A.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityTransfected
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Observed Molecular WeightObserved band size: 22 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Purified recombinant human GADD45 α protein expressed in E.coli
Transfected
affinity chromatography.
Non-conjugated
Unmodified
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GADD45A Antibod is an In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase
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Subcellular Localization
Nucleus
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Expression
Induction:By UV irradiation, X-rays, growth arrest and alkylating agents. The induction is mediated by some kinase (s) other than PKC -
Isoforms & Post-Translational Modification
P24522 has 2 isomers: P24522-1: 18336 Da (predicted); P24522-2: 14622 Da (predicted).
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Subunit
Interacts with MAPK14 (By similarity). Predominantly monomeric but also forms dimers and other oligomers as concentration increases. Interacts with GADD45GIP1. Interacts weakly with PCNA. Interacts with AURKA, likely to compete with dimerization
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SwissProt ID
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Synonyms
DDIT 1; DDIT-1; DDIT1; DNA damage inducible transcript 1; DNA damage-inducible transcript 1 protein; GA45A_HUMAN; GADD45; GADD45A; Growth arrest and DNA damage inducible 45 alpha; Growth arrest and DNA damage inducible alpha; Growth arrest and DNA damage-inducible protein GADD45 alpha.
Documentation
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