GADD45A - growth arrest and DNA damage inducible alpha Gene

Also Known as DDIT1; GADD45

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1647

About GADD45A

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:67,685,201-67,688,334 (from NCBI)

This gene has 7 transcripts (splice variants), 261 orthologues and 2 paralogues. Broad expression in liver (RPKM 72.1), kidney (RPKM 57.9) and 23 other tissues.

Summary

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]

GADD45A Products (3)

mRNA	Protein	Name
NM_001199741.2	NP_001186670.1	growth arrest and DNA damage-inducible protein GADD45 alpha isoform 2
NM_001199742.2	NP_001186671.1	growth arrest and DNA damage-inducible protein GADD45 alpha isoform 3
NM_001924.4	NP_001915.1	growth arrest and DNA damage-inducible protein GADD45 alpha isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables kinase binding	IPI IPI: Inferred from physical interaction	20460379	GOA
enables protein binding	IDA IDA: Inferred from direct assay	20460379	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12716909	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	20460379	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	20460379	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to ionizing radiation	IMP IMP: Inferred from mutant phenotype	20160708	GOA
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19593445	GOA
involved in negative regulation of blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	23329839	GOA
involved in negative regulation of peptidyl-serine phosphorylation of STAT protein	IMP IMP: Inferred from mutant phenotype	23329839	GOA
involved in negative regulation of protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	23329839	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23329839	GOA
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	9827804	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	9827804	GOA
involved in positive regulation of p38MAPK cascade	IDA IDA: Inferred from direct assay	9827804	GOA
involved in positive regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	20160708	GOA
involved in signal transduction in response to DNA damage	IMP IMP: Inferred from mutant phenotype	20160708	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9827804	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9827804	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GADD45A Protein Structure

Ribosomal_L7Ae

0
100
165 a.a.

Protein Preferred Names	Protein Names
growth arrest and DNA damage-inducible protein GADD45 alpha	DDIT-1

GADD45A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GADD45A	P24522	CNOT9	Homo sapiens	Q92600-3	Validated Y2H	32296183
Intra	GADD45A	P24522	NUCB2	Homo sapiens	P80303	Anti Tag CoIP	21988832
Intra	GADD45A	P24522	SH3GLB1	Homo sapiens	Q9Y371	Y2H	21988832
Intra	GADD45A	P24522	PCNA	Homo sapiens	P12004	Lumier	32814053
Intra	GADD45A	P24522	GADD45GIP1	Homo sapiens	Q8TAE8	Pull Down	12716909
Intra	GADD45A	P24522	AICDA	Homo sapiens	Q9GZX7	Anti Tag CoIP	21722948
Cross	GADD45A	P24522	Aicda	Mus musculus	Q9WVE0	Anti Tag CoIP	23820005
Intra	GADD45A	P24522	PARVG	Homo sapiens	Q9HBI0	Validated Y2H	32296183
Intra	GADD45A	P24522	DCTN2	Homo sapiens	Q13561	Validated Y2H	32296183
Intra	GADD45A	P24522	DCTN2	Homo sapiens	Q13561	Y2H Pooling	16189514
Intra	GADD45A	P24522	DCTN2	Homo sapiens	Q13561	Y2H	21988832
Intra	GADD45A	P24522	ERCC5	Homo sapiens	P28715	Anti Bait CoIP	17268471
Intra	GADD45A	P24522	ERCC5	Homo sapiens	P28715	Pull Down	17268471

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GADD45A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70326	GADD45A/DDIT-1 Protein, Human (His)	P24522 (M1-R165)	≥ 95%, as determined by reducing SDS-PAGE.

GADD45A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81331	GADD45A Antibody (YA1076)	WB	Human, Mouse, Rat
HY-P81331A	GADD45A Antibody (YA1076)(PBS only)	WB	Human, Mouse, Rat
HY-P85606	GADD45A Antibod (YA5298)	WB	Transfected

Related Diseases

Diseases	Alias
Ataxia-Telangiectasia	Ataxia Telangiectasia Louis-Bar Syndrome AT At1 Ataxia-Telangiectasia Syndrome Ataxia - Telangiectasia Variant Boder-Sedgwick Syndrome Louis Bar Syndrome Cerebello-Oculocutaneous Telangiectasia Immunodeficiency With Ataxia Telangiectasia A-T Ataxia Telangiectasia Syndrome Atm Telangiectasia, Cerebello-Oculocutaneous Ataxia-Telangiectasia Variant
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Ureteral Obstruction
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Li-Fraumeni Syndrome	Sarcoma Family Syndrome Of Li And Fraumeni Sbla Syndrome LFS Li-Fraumeni Familiar Cancer Susceptibility Syndrome Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome Lfs1 Li Fraumeni Syndrome Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome Lfl Sbla Syndrome Li-Fraumeni-Like Syndrome Li-Fraumeni Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10587	BIX-01294		98.44%	Unkown
HY-108239	BIX-01294 trihydrochloride		99.68%	Unkown
HY-RS05229	GADD45A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-136893	SP-6-27		/	Unkown
HY-RS17861	Gadd45a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24330	Gadd45a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GADD45A	VGNC	VGNC:80215
Canis familiaris	GADD45A	VGNC	VGNC:41069
Bos taurus	GADD45A	VGNC	VGNC:29206
Macaca mulatta	GADD45A	VGNC	VGNC:106369
Rattus norvegicus	GADD45A	RGD	RGD:2654
Mus musculus	GADD45A	MGD	MGI:107799
Others	GADD45A	NCBI