GATM Antibody (YA8060)(PBS only)

Cat. No.: HY-P88376A: Data Sheet User Guide for Antibodies
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GATM Antibody (YA8060) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GATM.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

GATM Antibody (YA8060) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GATM.

Host

Mouse

Molecular Weight

Predicted band size: 44.2 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P50440

Immunogen

Full length human recombinant protein of human GATM produced in HEK293 cell.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250
FC FC: Flow Cytometry	1:100

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives (PubMed:16820567, PubMed:27233232, PubMed:36543883, PubMed:3800397). Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain (Probable) (PubMed:27233232, PubMed:36543883, PubMed:3800397, PubMed:9266688)

Subcellular Localization：Mitochondrion inner membrane,Cytoplasm

Expression：
Tissue_Specificity: Expressed in brain, heart, kidney, liver, lung, salivary gland and skeletal muscle tissue, with the highest expression in kidney. Biallelically expressed in placenta and fetal tissues
Induction: Expression is elevated in the myocardium during heart failure, and decreased in inter-uterine growth restriction (IUGR)-associated placenta

Isoforms & Post-Translational Modification：P50440 has three isomers: P50440-1: 48455 Da (predicted); P50440-2: 44883 Da (predicted); P50440-3: 44943 Da (predicted).

Subunit：Homodimer

Synonyms

AGAT; AT; CCDS3

Documentation

User Guide for Antibodies (1077 KB)