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GATM Antibody (YA8060)(PBS only)

(Synonyms: AGAT; AT; CCDS3)

GATM Antibody (YA8060) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GATM.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG

  • Application:

    WB, IHC-P, ICC/IF, FC

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • GATM Antibody (YA8060)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
Dilution Ratio 1:1000-4000 1:150-500 1:100-250 1:100

Product Details

Description

GATM Antibody (YA8060) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GATM.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 44.2 kDa
Immunogen

Full length human recombinant protein of human GATM produced in HEK293 cell.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    GATM is a Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain (Probable)[1][2][3][4][5].

  • Subcellular Localization

    Mitochondrion inner membrane,Cytoplasm

  • Expression


    Tissue_Specificity: Expressed in brain, heart, kidney, liver, lung, salivary gland and skeletal muscle tissue, with the highest expression in kidney. Biallelically expressed in placenta and fetal tissues
    Induction: Expression is elevated in the myocardium during heart failure, and decreased in inter-uterine growth restriction (IUGR)-associated placenta

  • Isoforms & Post-Translational Modification

    P50440 has three isomers: P50440-1: 48455 Da (predicted); P50440-2: 44883 Da (predicted); P50440-3: 44943 Da (predicted).

  • Subunit

    Homodimer

  • SwissProt ID

    P50440

  • Synonyms

    AGAT; AT; CCDS3

GATM Antibody (YA8060)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • GATM Antibody (YA8060)(PBS only) Product Image