GPNMB Antibody (YA9693)
(Synonyms: Glycoprotein (transmembrane) nmb, Glycoprotein nmb, Glycoprotein nmb like protein, Gpnmb, GPNMB_HUMAN, HGFIN, NMB, Osteoactivin, Transmembrane glycoprotein, Transmembrane glycoprotein HGFIN)GPNMB Antibody (YA9693) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to GPNMB.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|---|---|
| Dilution Ratio | 1:1000 | 1:100 | 1:200 | 1:500-1000 |
Product Details
GPNMB Antibody (YA9693) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to GPNMB.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 64 kDa;
Recombinant protein of human GPNMB (aa 1-498).
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GPNMB is a Could be a melanogenic enzyme
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Subcellular Localization
Cell membrane; Melanosome membrane; Early endosome membrane
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Expression
Tissue_Specificity: Widely expressed, but very low expression, if any, in the brain. Expressed in the epidermis with higher levels in melanocytes compared with keratinocytes and Langerhans cells (at protein level). Expressed in peripheral blood, but not bone marrow mononuclear cells. Expressed in tissue macrophages, including liver Kuppfer cells and lung alveolar macrophages, in podocytes and in some cells of the ciliary body of the eye (at protein level). May be overexpressed in various cancers, including melanoma and glioblastoma multiforme.
Induction: Up-regulated by G-CSF/CSF3 and M-CSF/CSF1 in bone marrow mononuclear cells, hence up-regulation may be linked to differentiation. -
Isoforms & Post-Translational Modification
GPNMB has 2 isoforms, Q14956-1: amino acid length is 572, molecular weight is 63923 Da (predicted); Q14956-2: amino acid length is 560, molecular weight is 62643 Da (predicted).
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SwissProt ID
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Synonyms
Glycoprotein (transmembrane) nmb, Glycoprotein nmb, Glycoprotein nmb like protein, Gpnmb, GPNMB_HUMAN, HGFIN, NMB, Osteoactivin, Transmembrane glycoprotein, Transmembrane glycoprotein HGFIN
Documentation
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