HIP2/LIG Antibody (YA6593)
(Synonyms: E2 25K antibody; E2(25K) antibody; HIP-2 antibody; Huntingtin interacting protein 2 antibody; Huntingtin-interacting protein 2 antibody; HYPG antibody; LIG antibody; UBC1 antibody; UBE2K antibody; UBE2K_HUMAN antibody; E2 25K antibody; E2(25K) antibody; HIP-2 antibody; Huntingtin interacting protein 2 antibody; Huntingtin-interacting protein 2 antibody; HYPG antibody; LIG antibody; UBC1 antibody; UBE2K antibody; UBE2K_HUMAN antibody; Ubiquitin carrier protein antibody; Ubiquitin conjugating enzyme E2 25 kDa antibody; ubiquitin conjugating enzyme E2K antibody; ubiquitin conjugating enzyme E2K (UBC1 homolog, yeast) antibody; Ubiquitin protein ligase antibody; Ubiquitin-conjugating enzyme E2 K antibody; Ubiquitin-conjugating enzyme E2(25K) antibody; Ubiquitin-conjugating enzyme E2-25 kDa antibody; Ubiquitin-conjugating enzyme E2-25K antibody; Ubiquitin-protein ligase antibody; )HIP2/LIG Antibody (YA6593) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HIP2/LIG.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF, IHC-P, FC
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Reactivity :
Human, Mouse, Rat, Monkey
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|---|---|
| Dilution Ratio | 1:2000 | 1:100 | 1:1000 | 1:1000 |
Product Details
HIP2/LIG Antibody (YA6593) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HIP2/LIG.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat, Monkey
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Observed Molecular WeightObserved band size: 25 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 22 kDa
Recombinant protein within human HIP2 aa 1-200.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
HIP2/LIG is an Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1
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Subcellular Localization
Cytoplasm
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Expression
Tissue_Specificity: Expressed in all tissues tested, including spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, T-lymphocytes, monocytes, granulocytes and bone marrow mononuclear cells. Highly expressed in brain, with highest levels found in cortex and striatum and at lower levels in cerebellum and brainstem
Induction: By aggregated low-density lipoprotein -
Isoforms & Post-Translational Modification
P61086 has three isomers: P61086-1: 22407 Da (predicted); P61086-2: 16618 Da (predicted); P61086-3: 17447 Da (predicted).
Sumoylation at Lys-14 impairs catalytic activity -
Subunit
Interacts with RNF138/NARF
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SwissProt ID
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Synonyms
E2 25K antibody; E2(25K) antibody; HIP-2 antibody; Huntingtin interacting protein 2 antibody; Huntingtin-interacting protein 2 antibody; HYPG antibody; LIG antibody; UBC1 antibody; UBE2K antibody; UBE2K_HUMAN antibody; E2 25K antibody; E2(25K) antibody; HIP-2 antibody; Huntingtin interacting protein 2 antibody; Huntingtin-interacting protein 2 antibody; HYPG antibody; LIG antibody; UBC1 antibody; UBE2K antibody; UBE2K_HUMAN antibody; Ubiquitin carrier protein antibody; Ubiquitin conjugating enzyme E2 25 kDa antibody; ubiquitin conjugating enzyme E2K antibody; ubiquitin conjugating enzyme E2K (UBC1 homolog, yeast) antibody; Ubiquitin protein ligase antibody; Ubiquitin-conjugating enzyme E2 K antibody; Ubiquitin-conjugating enzyme E2(25K) antibody; Ubiquitin-conjugating enzyme E2-25 kDa antibody; Ubiquitin-conjugating enzyme E2-25K antibody; Ubiquitin-protein ligase antibody;
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