HIRA Antibody (YA2782)

Cat. No.: HY-P83037: Data Sheet COA
SDS
User Guide for Antibodies
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HIRA Antibody (YA2782) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HIRA.

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사이즈	재고	수량
20 μL	해외재고보유	Estimated Time of Arrival: December 31
50 μL	해외재고보유	Estimated Time of Arrival: December 31
100 μL	해외재고보유	Estimated Time of Arrival: December 31
250 μL	견적 받기

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HIRA Antibody (YA2782) Featured Recommendations:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명

제품 설명

HIRA Antibody (YA2782) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HIRA.

Host

Rabbit

Clonality

Recombinant,Monoclonal

분자량

Predicted band size: 112 kDa;

Observed band size: 112 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

P54198

Gene ID

7290 [NCBI]

Immunogen

A synthesized peptide derived from human HIRA aa950-1017/1017.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-1:2000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-1:200
FC FC: Flow Cytometry	1:50-1:100
IP IP: Immunoprecipitation	1:50

Sensitivity	Endogenous	Purity	Affinity Purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit

Subcellular Localization：Nucleus; Nucleus, PML body

Expression：
Tissue_specificity:Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta

Isoforms & Post-Translational Modification：P54198 has 2 isomers: P54198-1: 111835 Da (predicted); P54198-2: 89299 Da (predicted).
Sumoylated;Phosphorylated by CDK2/CCNA1 and CDK2/CCNE1 on Thr-555 in vitro. Also phosphorylated on Thr-555 and Ser-687 in vivo

Subunit：Interacts with histone H3-3B, PAX3 and PAX7 (By similarity). Interacts with histone H3.Y (PubMed:28334823). Interacts with CCNA1, HIRIP3, NFU1/HIRIP5 and histone H2B. Part of a complex which includes ASF1A, CABIN1, histone H3.3, histone H4 and UBN1 (PubMed:11238922, PubMed:14680630, PubMed:14718166, PubMed:15621527, PubMed:16980972, PubMed:19029251, PubMed:9710638)

Database

Entrez Gene: 7290 Human

SwissProt: P54198 Human

OMIM: 600237 Human

Research Field

Epigenetics and Nuclear Signaling

Synonyms

DGCR1; HIR; HIRA; TUP 1; TUPLE1

각종 서류

Select Batch:

Data Sheet (234 KB) SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

HIRA Antibody (YA2782) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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HIRA Antibody (YA2782)

HIRA Antibody (YA2782) Featured Recommendations:

Product Detail

Background

제품 설명

HIRA Antibody (YA2782) Related Classifications

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SAFETY DATA SHEET (SDS)

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