HSPA6 Antibody (YA7825)
(Synonyms: heat shock 70kDa protein 6 (HSP70B'); heat shock 70kD protein 6 (HSP70B'))
Based on 1 Customer Validation
HSPA6 Antibody (YA7825) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to HSPA6.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
WB, ICC/IF, FC
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
|
|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:100-250 | 1:100 |
Product Details
HSPA6 Antibody (YA7825) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to HSPA6.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 70.8 kDa
Full length human recombinant protein of human HSPA6 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
HSPA6 is a Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release[1].
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Expression
Induction: Only at higher temperatures, and no basal expression
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Isoforms & Post-Translational Modification
P17066: 643 amino acids, molecular weight 71028 Da.
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SwissProt ID
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Synonyms
heat shock 70kDa protein 6 (HSP70B'); heat shock 70kD protein 6 (HSP70B')
Documentation
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