Huntingtin Antibody (YA7211)
(Synonyms: HD, IT15, HTT, Huntingtin, Huntington disease protein, HD protein)
Based on 1 Customer Validation
Huntingtin Antibody (YA7211) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Huntingtin.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IHC-F, IF-Tissue, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 0.01M tris buffered saline (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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FC
FC: Flow Cytometry
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|---|---|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-500 | 1:100-500 | 1:100-500 | 1μg/Test |
Product Details
Huntingtin Antibody (YA7211) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Huntingtin.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 350 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 347 kDa
A synthesized peptide derived from human Huntingtin: 1-47.
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 0.01M tris buffered saline (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Huntingtin (HTT) is a soluble 3144 amino acid (348 kDa) protein, with the highest levels of expression being found in the CNS and testes. An abnormal expansion of a glutamine stretch (polyQ) in N-terminal sequence of huntingtin leads to the devastating neurodegenerative disorder Huntington's disease (HD) . Subcellular fractionation and microscopic studies have shown that huntingtin is associated with vesicles and microtubules by interacting with huntingtin-associated protein 1 (HAP1), which is reported to form a complex with the dynactin and modulate or regulate the dynein–dynactin complex. There is evidence that huntingtin participates in post-Golgi trafficking of proteins that follow the regulated secretory pathway.
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Subcellular Localization
Cytoplasm,Nucleus,Early endosome,Cytoplasmic vesicle, autophagosome
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Expression
Tissue_Specificity: Expressed in the brain cortex (at protein level). Widely expressed with the highest level of expression in the brain (nerve fibers, varicosities, and nerve endings). In the brain, the regions where it can be mainly found are the cerebellar cortex, the neocortex, the striatum, and the hippocampal formation -
Isoforms & Post-Translational Modification
P42858: 3142 amino acids, molecular weight 347603 Da.
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Subunit
Interacts with PFN1 (PubMed:18573880)
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SwissProt ID
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Synonyms
HD, IT15, HTT, Huntingtin, Huntington disease protein, HD protein
Documentation
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