KSHV ORF45 Antibody (YA4607)
(Synonyms: ORF45)
Based on 1 Customer Validation
KSHV ORF45 Antibody (YA4607) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KSHV ORF45.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ELISA
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Reactivity :
KSHV
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Formulation:
Supplied in PBS with 0.05% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:10000 |
Product Details
KSHV ORF45 Antibody (YA4607) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KSHV ORF45.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityKSHV
Purified recombinant fragment of KSHV ORF45 aa 65-214.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
KSHV ORF45 prevents the establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of host interferon regulatory factor 7/IRF7, a transcription factor critical for the induction of interferons alpha and beta. Mechanistically, ORF45 competes with the associated IRF7 and inhibits its phosphorylation by IKBKE or TBK1 by acting as an alternative substrate. Acts as an activator of the NLRP1 inflammasome via interaction with the N-terminal part of host NLRP1: interaction promotes translocation of the N-terminal part of NLRP1 into the nucleus, relieving autoinhibition of the NLRP1 inflammasome and leading to its activation. Also plays a role in promoting the late transcription and translation of viral lytic genes by constitutively activating host extracellular signal-regulated kinase (ERK)-p90 ribosomal S6 kinase/RPS6KA1. In addition, supports the viral replication cycle by modulating host p53/TP53 signaling pathway. Interacts with host p53/TP53 and prevents its interaction with the deubiquitinase USP7, leading to sequestration of P53/TP53 in the host cytoplasm thereby diminishing its transcriptional activity[1][2][3][4][5][6].
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Subcellular Localization
Virion tegument; Host cytoplasm; Host nucleus; Host Golgi apparatus
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Subunit
Interacts with host IRF7 (PubMed:11943871). Interacts with host RPS6KA1 (PubMed:30842327). Interacts with host RAB11FIP5; this interaction results in the lysosomal degradation of ORF45 and the inhibition of viral particle release (PubMed:33315947). Interacts with host p53/TP53; this interaction down-regulates p53/TP53 signaling pathway (PubMed:34523970). Interacts with the N-terminal part of host NLRP1; relieving autoinhibition of the NLRP1 inflammasome (PubMed:35618833)
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SwissProt ID
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Synonyms
ORF45
Documentation
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Data Sheet (234 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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User Guide for Antibodies (1077 KB)
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