Lamin B Receptor Antibody (YA3151)(PBS only)
(Synonyms: PHA; LMN2R; TDRD18; DHCR14B; LBR)Lamin B Receptor Antibody (YA3151) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lamin B Receptor.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, FC
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Reactivity :
Human, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 | 1:200-1:500 | 1:200-1:1000 |
Product Details
Lamin B Receptor Antibody (YA3151) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lamin B Receptor.
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Host Rabbit
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Species ReactivityHuman, Rat
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Observed Molecular WeightObserved band size: 71 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 71 kDa
A synthetic peptide of human Lamin B Receptor
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Lamin B Receptor catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis. Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation. Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation. Anchors the lamina and the heterochromatin to the inner nuclear membrane[1][2][3][4][5][6].
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Subcellular Localization
Nucleus inner membrane; Multi-pass membrane protein; Endoplasmic reticulum membrane; Cytoplasm; Nucleus
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Expression
Tissue_specificity:Expressed in the bone marrow, liver, heart, adrenal gland, lung, placenta and uterus (PubMed:16784888) . Expressed in osteoclasts and osteoblast-like cells (PubMed:21327084) -
Subunit
Interacts with CBX5 (PubMed:15882967, PubMed:9169472). Interacts with DNA (PubMed:8157662). Interaction with DNA is sequence independent with higher affinity for supercoiled and relaxed circular DNA than linear DNA (PubMed:8157662). Interacts with lamin B (PubMed:8157662). Interacts with CLNK (PubMed:26009488). Interacts with TMEM147; promoting LBR localization to the nucleus inner membrane (PubMed:32694168)
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SwissProt ID
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Synonyms
PHA; LMN2R; TDRD18; DHCR14B; LBR
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Research Field
Tags & Cell Markers
Documentation
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