Lamin B Receptor Antibody (YA3151)(PBS only)

Cat. No.: HY-P83406A: Data Sheet User Guide for Antibodies
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Lamin B Receptor Antibody (YA3151) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lamin B Receptor.

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사이즈		재고
50 μL		견적 받기
100 μL		견적 받기

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명

제품 설명

Lamin B Receptor Antibody (YA3151) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lamin B Receptor.

Host

Rabbit

분자량

Predicted band size: 71 kDa;

Observed band size: 71 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Rat

SwissProt ID

Q14739

Gene ID

3930 [NCBI]

Immunogen

A synthetic peptide of human Lamin B Receptor

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-1:100
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:200-1:500
FC FC: Flow Cytometry	1:200-1:1000

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722, PubMed:9630650). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963)

Subcellular Localization：Nucleus inner membrane; Multi-pass membrane protein; Endoplasmic reticulum membrane; Cytoplasm; Nucleus

Expression：
Tissue_specificity:Expressed in the bone marrow, liver, heart, adrenal gland, lung, placenta and uterus (PubMed:16784888) . Expressed in osteoclasts and osteoblast-like cells (PubMed:21327084)

Subunit：Interacts with CBX5 (PubMed:15882967, PubMed:9169472). Interacts with DNA (PubMed:8157662). Interaction with DNA is sequence independent with higher affinity for supercoiled and relaxed circular DNA than linear DNA (PubMed:8157662). Interacts with lamin B (PubMed:8157662). Interacts with CLNK (PubMed:26009488). Interacts with TMEM147; promoting LBR localization to the nucleus inner membrane (PubMed:32694168)

Research Field

Tags & Cell Markers

Synonyms

PHA; LMN2R; TDRD18; DHCR14B; LBR

각종 서류

User Guide for Antibodies (1077 KB)