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Cat. No.: HY-P83406

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Lamin B Receptor Antibody (YA3151)

Name: Lamin B Receptor Antibody (YA3151)
Brand: MedChemExpress
SKU: HY-P83406
Price: 146.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: PHA; LMN2R; TDRD18; DHCR14B; LBR)

Customer Review

Based on 1 Customer Validation

Lamin B Receptor Antibody (YA3151) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lamin B Receptor.

For research use only. We do not sell to patients.

Host:
Rabbit
Isotype:
IgG
Application:
WB, IHC-P, ICC/IF, FC
Reactivity :
Human, Rat

Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Conjugation:
Non-conjugated

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Price

Stock

Quantity

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications
Product Details
Product Properties
- Appearance
- Formulation
- Concentration
- Storage & Stability
- Shipping
Background
Documentation
References
Help & FAQs
Classifications
Bioz

Applications

Application	WB WB: Western Blot	IHC-P IHC-P: Immunohistochemistry-Paraffin	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	FC FC: Flow Cytometry
Dilution Ratio	1:500-1:1000	1:50-1:100	1:200-1:500	1:200-1:1000

Product Details

Description

Lamin B Receptor Antibody (YA3151) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lamin B Receptor.

Host Rabbit
Clonality Recombinant,Monoclonal
Species Reactivity
Human, Rat
Observed Molecular Weight

Observed band size: 58-65 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 71 kDa

Species Reactivity Database

Entrez Gene: 3930 Human

SwissProt: Q14739 Human

OMIM: 169400 Human

Immunogen

A synthetic peptide of human Lamin B Receptor

Sensitivity

Endogenous

Purification

Affinity Purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

Appearance

Solution
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration

Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Background

Function

Lamin B Receptor catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis. Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation. Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation. Anchors the lamina and the heterochromatin to the inner nuclear membrane^[1]^[2]^[3]^[4]^[5]^[6].
Subcellular Localization

Nucleus inner membrane; Multi-pass membrane protein; Endoplasmic reticulum membrane; Cytoplasm; Nucleus
Expression

Tissue_specificity:Expressed in the bone marrow, liver, heart, adrenal gland, lung, placenta and uterus (PubMed:16784888) . Expressed in osteoclasts and osteoblast-like cells (PubMed:21327084)
Subunit

Interacts with CBX5 (PubMed:15882967, PubMed:9169472). Interacts with DNA (PubMed:8157662). Interaction with DNA is sequence independent with higher affinity for supercoiled and relaxed circular DNA than linear DNA (PubMed:8157662). Interacts with lamin B (PubMed:8157662). Interacts with CLNK (PubMed:26009488). Interacts with TMEM147; promoting LBR localization to the nucleus inner membrane (PubMed:32694168)
SwissProt ID

Q14739
Gene ID

3930 [NCBI]
Synonyms

PHA; LMN2R; TDRD18; DHCR14B; LBR
Research Field

Tags & Cell Markers

Documentation

Select Batch:

Data Sheet (261 KB)
SDS (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
User Guide for Antibodies (1077 KB)

References

[1]. Waterham HR, et al. Autosomal recessive HEM/Greenberg skeletal dysplasia is caused by 3 beta-hydroxysterol delta 14-reductase deficiency due to mutations in the lamin B receptor gene. Am J Hum Genet. 2003 Apr;72(4):1013-7. [Content Brief]

[2]. Bennati AM, et al. Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis. Biochim Biophys Acta. 2006 Jul;1761(7):677-85. [Content Brief]

[3]. Clayton P, et al. Mutations causing Greenberg dysplasia but not Pelger anomaly uncouple enzymatic from structural functions of a nuclear membrane protein. Nucleus. 2010 Jul-Aug;1(4):354-66. [Content Brief]

[4]. Tsai PL, et al. The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations. Elife. 2016 Jun 23;5:. [Content Brief]

[5]. Silve S, et al. Human lamin B receptor exhibits sterol C14-reductase activity in Saccharomyces cerevisiae. Biochim Biophys Acta. 1998 Jun 15;1392(2-3):233-44. [Content Brief]

[6]. Duband-Goulet I, et al. Inner nuclear membrane protein LBR preferentially interacts with DNA secondary structures and nucleosomal linker. Biochemistry. 2000 May 30;39(21):6483-8. [Content Brief]