NAPEPLD (NAPE-PLD) Antibody (YA7783)
(Synonyms: FMP30; NAPE-PLD)NAPEPLD (NAPE-PLD) Antibody (YA7783) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NAPEPLD (NAPE-PLD).
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P, ICC/IF, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100-250 | 1:100 |
Product Details
NAPEPLD (NAPE-PLD) Antibody (YA7783) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NAPEPLD (NAPE-PLD).
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 45.4 kDa
Full length human recombinant protein of human NAPEPLD produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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선적
Shipping with blue ice.
Background
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Function
D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid (PubMed:14634025, PubMed:16527816, PubMed:25684574, PubMed:27571266). Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain (By similarity). May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation (By similarity). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs (By similarity)
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Subcellular Localization
Golgi apparatus membrane,Early endosome membrane,Nucleus envelope,Nucleus, nucleoplasm
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Expression
Tissue_Specificity: Widely expressed. Highest expression in brain, kidney and testis (at protein level). Expressed in adipose tissue (at protein level) -
Isoforms & Post-Translational Modification
Q6IQ20: 393 amino acids, molecular weight 45596 Da.
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Subunit
Homodimer
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SwissProt ID
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Synonyms
FMP30; NAPE-PLD
각종 서류
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