Nectin-3/CD113 Antibody (YA7094)(PBS only)

Cat. No.: HY-P87406A: Data Sheet User Guide for Antibodies
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Nectin-3/CD113 Antibody (YA7094) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Nectin-3/CD113.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Nectin-3/CD113 Antibody (YA7094) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Nectin-3/CD113.

Host

Mouse

Molecular Weight

Predicted band size: 61kDa;

Species Reactivity

Human

SwissProt ID

Q9NQS3

Immunogen

Purified recombinant fragment of human CD113 (AA: extra 282-404) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
FC FC: Flow Cytometry	1:200-1:400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Solution

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Cell adhesion molecule that promotes cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions (PubMed:16216929). Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1 (PubMed:16216929). Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation (PubMed:16216929). Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells (By similarity). Also involved in the formation of cell-cell junctions, including adherens junctions and synapses (By similarity). Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN1: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types (By similarity). Plays a role in the morphology of the ciliary body (By similarity)

Subcellular Localization：Cell membrane,Postsynaptic cell membrane,Cell junction, adherens junction

Expression：
Tissue_Specificity: Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines

Isoforms & Post-Translational Modification：Q9NQS3 has three isomers: Q9NQS3-1: 61002 Da (predicted); Q9NQS3-2: 39692 Da (predicted); Q9NQS3-3: 54375 Da (predicted).

Subunit：Cis- and trans-homodimer

Synonyms

CD113, PRR3, PVRL3, NECTIN3, Nectin-3, CDw113, Nectin cell adhesion molecule 3, Poliovirus receptor-related protein 3

Documentation

User Guide for Antibodies (1077 KB)