Nectin-3/CD113 Antibody (YA7094)(PBS only)
(Synonyms: CD113, PRR3, PVRL3, NECTIN3, Nectin-3, CDw113, Nectin cell adhesion molecule 3, Poliovirus receptor-related protein 3)Nectin-3/CD113 Antibody (YA7094) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Nectin-3/CD113.
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Host:
Mouse
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Isotype:
IgG1
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Application:
FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:200-1:400 | 1:10000 |
Product Details
Nectin-3/CD113 Antibody (YA7094) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Nectin-3/CD113.
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Host Mouse
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 61kDa;
Purified recombinant fragment of human CD113 (AA: extra 282-404) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG1
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Nectin-3/CD113 cell adhesion molecule that promotes cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN1: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types. Plays a role in the morphology of the ciliary body[1].
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Subcellular Localization
Cell membrane,Postsynaptic cell membrane,Cell junction, adherens junction
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Expression
Tissue_Specificity: Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines -
Isoforms & Post-Translational Modification
Q9NQS3 has three isomers: Q9NQS3-1: 61002 Da (predicted); Q9NQS3-2: 39692 Da (predicted); Q9NQS3-3: 54375 Da (predicted).
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Subunit
Cis- and trans-homodimer
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SwissProt ID
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Synonyms
CD113, PRR3, PVRL3, NECTIN3, Nectin-3, CDw113, Nectin cell adhesion molecule 3, Poliovirus receptor-related protein 3
Documentation
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