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NPM3 Antibody (YA3562)(PBS only)

(Synonyms: PORMIN; TMEM123)

NPM3 Antibody (YA3562) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NPM3.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    IHC-P, ICC/IF, FC, ELISA

  • Reactivity :

    Human, Mouse

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • NPM3 Antibody (YA3562)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:200-1:1000 1:50-1:200 1:200-1:400 1:10000

Product Details

Description

NPM3 Antibody (YA3562) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NPM3.

  • Host Mouse
  • Species Reactivity
    Human, Mouse
  • Observed Molecular Weight
    Observed band size: 19 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 19 kDa
Immunogen

Purified recombinant fragment of human NPM3 (AA: full 1-178) expressed in E. Coli.

Purification

affinity purified.

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    NPM3 plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning. Modulates the histone chaperone function and the RNA-binding activity of nucleolar phosphoprotein B23/NPM. Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM[1][2][3].

  • Subcellular Localization

    Nucleus; Nucleus, nucleolus

  • Expression


    Tissue_specificity:Ubiquitous

  • Subunit

    Interacts with NPM (via N-terminus) (PubMed:15596447). Forms a pentamer with NPM at a ratio 4:1 (NPM3/NPM). Two pentamers form a decamer (PubMed:22362753)

  • SwissProt ID

    O75607

  • Gene ID
    10360 [NCBI]
  • Synonyms

    PORMIN; TMEM123

NPM3 Antibody (YA3562)(PBS only) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • NPM3 Antibody (YA3562)(PBS only) Product Image