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OSBPL11 Antibody (YA8233)(PBS only)

(Synonyms: ORP-11; ORP11; OSBP12; TCCCIA00292)

OSBPL11 Antibody (YA8233) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to OSBPL11.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    ICC/IF, FC

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • OSBPL11 Antibody (YA8233)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
Dilution Ratio 1:100-250 1:100

Product Details

Description

OSBPL11 Antibody (YA8233) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to OSBPL11.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 83.5 kDa
Immunogen

Full length human recombinant protein of human OSBPL11 produced in HEK293T cell.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    OSBPL11 plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage. Weakly binds 25-hydroxycholesterol. Interacts with OSBPL9 to function as lipid transfer proteins. Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex[1][2][3].

  • Subcellular Localization

    Late endosome membrane,Golgi apparatus, trans-Golgi network membrane

  • Expression


    Tissue_Specificity: Present at highest levels in ovary, testis, kidney, liver, stomach, brain, and adipose tissue. Strong expression (at protein level) in epithelial cells of kidney tubules, testicular tubules, caecum, and skin (PubMed:20599956). Present at low levels in subcutaneous and visceral adipose tissue (at protein level) (PubMed:23028956)

  • Isoforms & Post-Translational Modification

    Q9BXB4: 747 amino acids, molecular weight 83643 Da.

  • Subunit

    Heterodimer with OSBPL9

  • SwissProt ID

    Q9BXB4

  • Synonyms

    ORP-11; ORP11; OSBP12; TCCCIA00292

OSBPL11 Antibody (YA8233)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • OSBPL11 Antibody (YA8233)(PBS only) Product Image
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  • OSBPL11 Antibody (YA8233)(PBS only) Product Image