OSBPL11 Antibody (YA8233)
(Synonyms: ORP-11; ORP11; OSBP12; TCCCIA00292)OSBPL11 Antibody (YA8233) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to OSBPL11.
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Host:
Mouse
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Isotype:
IgG
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Application:
ICC/IF, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:100-250 | 1:100 |
Product Details
OSBPL11 Antibody (YA8233) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to OSBPL11.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 83.5 kDa
Full length human recombinant protein of human OSBPL11 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
OSBPL11 plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage. Weakly binds 25-hydroxycholesterol. Interacts with OSBPL9 to function as lipid transfer proteins. Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex[1][2][3].
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Subcellular Localization
Late endosome membrane,Golgi apparatus, trans-Golgi network membrane
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Expression
Tissue_Specificity: Present at highest levels in ovary, testis, kidney, liver, stomach, brain, and adipose tissue. Strong expression (at protein level) in epithelial cells of kidney tubules, testicular tubules, caecum, and skin (PubMed:20599956). Present at low levels in subcutaneous and visceral adipose tissue (at protein level) (PubMed:23028956) -
Isoforms & Post-Translational Modification
Q9BXB4: 747 amino acids, molecular weight 83643 Da.
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Subunit
Heterodimer with OSBPL9
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SwissProt ID
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Synonyms
ORP-11; ORP11; OSBP12; TCCCIA00292
Documentation
References
[1]. Zhou Y, et al. OSBP-related proteins (ORPs) in human adipose depots and cultured adipocytes: evidence for impacts on the adipocyte phenotype. PLoS One. 2012;7(9):e45352. [Content Brief]
[2]. Suchanek M, et al. The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket. Biochem J. 2007 Aug 1;405(3):473-80. [Content Brief]
[3]. Cabukusta B, et al. The ORP9-ORP11 dimer promotes sphingomyelin synthesis. Elife. 2024 Aug 6;12:. [Content Brief]
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