PAX6 Antibody (YA5999)
(Synonyms: Paired box protein Pax-6; Aniridia type II protein; Oculorhombin; )
Based on 1 Customer Validation
PAX6 Antibody (YA5999) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PAX6.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, IHC-P, ICC/IF, IP, ELISA
-
Reactivity :
Human, Mouse
-
Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
|
IP
IP: Immunoprecipitation
|
|---|---|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:2000-1:10000 | 1:200-1:1000 | 1:5000-1:20000 | 1:50-1:200 |
Product Details
PAX6 Antibody (YA5999) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PAX6.
-
Host Rabbit
-
Clonality Monoclonal
-
Species ReactivityHuman, Mouse
-
Observed Molecular WeightObserved band size: 47 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 47 kDa
The exact sequence is proprietary to MCE.
Protein A
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
-
Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
PAX6 transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains. Acts as a transcriptional repressor of NFATC1-mediated gene expression
-
Subcellular Localization
Nucleus; Nucleus; Nucleus
-
Expression
Tissue_specificity:It is expressed in lymphoblasts; it is weakly expressed in lymphoblasts. -
Isoforms & Post-Translational Modification
P26367 has 3 isomers: P26367-1: 46683 Da (predicted); P26367-2: 48218 Da (predicted); P26367-3: Da (predicted).
Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation -
Subunit
Interacts with MAF and MAFB (By similarity). Interacts with TRIM11; this interaction leads to ubiquitination and proteasomal degradation, as well as inhibition of transactivation, possibly in part by preventing PAX6 binding to consensus DNA sequences (By similarity). Interacts with TLE6/GRG6 (By similarity)
-
SwissProt ID
-
Synonyms
Paired box protein Pax-6; Aniridia type II protein; Oculorhombin;
Documentation
Powered by Bioz
