PR3 Antibody (YA5024)
(Synonyms: PRTN3; MBN; Myeloblastin; AGP7; C-ANCA antigen; Leukocyte proteinase 3; PR-3; PR3; Neutrophil proteinase 4; NP-4; P29; Wegener autoantigen)PR3 Antibody (YA5024) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PR3.
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Host:
Mouse
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Isotype:
IgG
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Application:
ICC/IF, FC, ELISA
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS with 0.05% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:50-1:200 | 1:200-1:400 | 1:10000 |
Product Details
PR3 Antibody (YA5024) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PR3.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse
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Calculated Molecular Weight Predicted band size: 28kDa;
Purified recombinant fragment of human Proteinase 3 expressed in E. Coli. The exact sequence is proprietary to MCE.
Endogenous
affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS with 0.05% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PR3 serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. Plays a role in neutrophil transendothelial migration, probably when associated with CD177. Triggers inflammatory processes in neutrophils by interacting with ADGRG3 upstream of F2RL1/PAR2 activation[1][2][3][4][5][6].
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Subcellular Localization
Cytoplasmic granule; Secreted; Cell membrane; Peripheral membrane protein; Extracellular side; Membrane raft; Peripheral membrane protein; Extracellular side
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Expression
Tissue_specificity:Expression at protein levels in polymorphonuclear leukocytes (PubMed:2033050, PubMed:3198760, PubMed:7897245) . Expression at protein levels in neutrophils (PubMed:17244676, PubMed:18462208, PubMed:21193407, PubMed:22266279, PubMed:28240246) . Expression in differentiating neutrophils (PubMed:18462208) .
Induction:Induced during CSF3/G-CSF-mediated neutrophil differentiation -
Subunit
May form dimers (PubMed:28240246). Interacts with CD177; the interaction tethers PRTN3 to the cell surface; the interaction is direct (PubMed:17244676, PubMed:28240246). Interacts with SERPINB1 (PubMed:30692621). Interacts with ADGRG3 (PubMed:36302784)
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SwissProt ID
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Synonyms
PRTN3; MBN; Myeloblastin; AGP7; C-ANCA antigen; Leukocyte proteinase 3; PR-3; PR3; Neutrophil proteinase 4; NP-4; P29; Wegener autoantigen
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