Presenilin 2 Antibody (YA1605)
(Synonyms: AD3LP; AD5; E5-1; STM-2)
Based on 1 Customer Validation
Presenilin 2 Antibody (YA1605) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Presenilin 2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, FC, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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IP
IP: Immunoprecipitation
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|---|---|---|---|---|---|
| Dilution Ratio | 1:1000-1:5000 | 1:200-1:500 | 1:50-1:200 | 1:20-1:50 | 1:20 |
Product Details
Presenilin 2 Antibody (YA1605) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Presenilin 2.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 23 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 50 kDa
Entrez Gene: 5664 Human ; 19165 Mouse ; 81751 Rat
SwissProt: P49810 Human ; Q61144 Mouse ; O88777 Rat
OMIM: 606889 Human
A synthetic peptide of human Presenilin 2
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Presenilin 2 is a Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria[1][2].
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Subcellular Localization
Endoplasmic reticulum membrane; Multi-pass membrane protein; Golgi apparatus membrane; Multi-pass membrane protein
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Expression
Tissue_specificity:Isomer 1 is found in the placenta, skeletal muscle, and heart, while isomer 2 is found in the heart, brain, placenta, liver, skeletal muscle, and kidneys. -
Isoforms & Post-Translational Modification
P49810 has 3 isomers: P49810-1: 50140 Da (predicted); P49810-2: 46387 Da (predicted); P49810-3: 50011 Da (predicted).
Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments;Phosphorylated on serine residues -
Subunit
Interacts with DOCK3 (By similarity). Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist. Interacts with HERPUD1, FLNA, FLNB and PARL
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SwissProt ID
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Synonyms
AD3LP; AD5; E5-1; STM-2
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Research Field
Neuroscience
Documentation
References
[1]. Tu H, et al. Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell. 2006 Sep 8;126(5):981-93. [Content Brief]
[2]. Zampese E, et al. Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2777-82. [Content Brief]
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