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Prolactin Receptor Antibody (YA2411)

(Synonyms: CPRLP; HPRL; hPRL receptor; Lactogen receptor; MFAB; OPR; Pr-1; Pr-3; PRLR; Prolactin receptor a)
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Based on 1 Customer Validation

Prolactin Receptor Antibody (YA2411) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Prolactin Receptor.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for Prolactin Receptor Antibody (YA2411)
  • Prolactin Receptor Antibody (YA2411) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
Dilution Ratio 1:500-1:1000

Product Details

Description

Prolactin Receptor Antibody (YA2411) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Prolactin Receptor.

  • Host Rabbit
  • Clonality Recombinant, Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 95 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 70 kDa
Species Reactivity Database
Immunogen

A synthesized peptide derived from human Prolactin Receptor aa50-87.

Sensitivity

Endogenous

Purification

Affinity Chromatography

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

RRID

AB_3104766

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Verification Images

  • Experimental Validation Results for Prolactin Receptor Antibody (YA2411)
    Western blot analysis of extracts from Jurkat(lane 2(20ug) and Jurkat(lane 3(40ug) using Prolactin Receptor Antibody (HY-P82666) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

Background

  • Function

    Prolactin Receptor is a This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling

  • Subcellular Localization

    Membrane; Single-pass type I membrane protein; Secreted

  • Expression


    Tissue_specificity:Expressed in breast, placenta, kidney, liver and pancreas

  • Isoforms & Post-Translational Modification

    P16471 has 9 isomers: P16471-1: 69506 Da (predicted); P16471-2: 57953 Da (predicted); P16471-3: 26545 Da (predicted); P16471-4: 42639 Da (predicted); P16471-5: 39806 Da (predicted); P16471-6: 32760 Da (predicted); P16471-7: 30705 Da (predicted); P16471-8: 24773 Da (predicted); P16471-9: 35011 Da (predicted).

  • Subunit

    Homodimer upon hormone binding. Interacts with SMARCA1. Interacts with GH1. Interacts with CSH. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent

  • SwissProt ID

    P16471

  • Gene ID
    5618 [NCBI]
  • Synonyms

    CPRLP; HPRL; hPRL receptor; Lactogen receptor; MFAB; OPR; Pr-1; Pr-3; PRLR; Prolactin receptor a

  • Research Field

    Signal Transduction

Prolactin Receptor Antibody (YA2411) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedChemExpress Validation
     Western blot analysis of extracts from Jurkat(lane 2(20ug) and Jurkat(lane 3(40ug) using Prolactin Receptor Antibody (HY-P82666) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

  • Prolactin Receptor Antibody (YA2411) Product Image
    1/16
  • Experimental Validation Results for Prolactin Receptor Antibody (YA2411)
  • Prolactin Receptor Antibody (YA2411) Product Image
  • Experimental Validation Results for Prolactin Receptor Antibody (YA2411)
    1/1
    MedChemExpress Validation
     Western blot analysis of extracts from Jurkat(lane 2(20ug) and Jurkat(lane 3(40ug) using Prolactin Receptor Antibody (HY-P82666) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
  • Experimental Validation Results for Prolactin Receptor Antibody (YA2411)
  • Prolactin Receptor Antibody (YA2411) Product Image
    MedChemExpress Validation

    Western blot analysis of extracts from Jurkat(lane 2(20ug) and Jurkat(lane 3(40ug) using Prolactin Receptor Antibody (HY-P82666) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

  • Prolactin Receptor Antibody (YA2411) Product Image WB