PRLR - prolactin receptor Gene

Also Known as HPRL; MFAB; hPRLrI; RI-PRLR

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5618

About PRLR

Cytogenetic location: 5p13.2 Genomic coordinates (GRCh38): 5:35,048,756-35,230,487 (from NCBI)

This gene has 20 transcripts (splice variants), 269 orthologues, 23 paralogues and is associated with 3 phenotypes. Biased expression in placenta (RPKM 18.9), endometrium (RPKM 11.6) and 8 other tissues.

Summary

This gene encodes a receptor for the anterior pituitary hormone, Prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the Prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of Prolactin in normal tissue and Cancer. [provided by RefSeq, Feb 2011]

PRLR Products (12)

mRNA	Protein	Name
NM_000949.7	NP_000940.1	prolactin receptor isoform 1 precursor
NM_001204314.2	NP_001191243.1	prolactin receptor isoform 6 precursor
NM_001204315.1	NP_001191244.1	prolactin receptor isoform 2 precursor
NM_001204316.1	NP_001191245.1	prolactin receptor isoform 3 precursor
NM_001204317.1	NP_001191246.1	prolactin receptor isoform 4 precursor
NM_001204318.1	NP_001191247.1	prolactin receptor isoform 5 precursor
NM_000949.7	NP_000940.1	prolactin receptor isoform 1 precursor
NM_001204314.2	NP_001191243.1	prolactin receptor isoform 6 precursor
NM_001204315.1	NP_001191244.1	prolactin receptor isoform 2 precursor
NM_001204316.1	NP_001191245.1	prolactin receptor isoform 3 precursor
NM_001204317.1	NP_001191246.1	prolactin receptor isoform 4 precursor
NM_001204318.1	NP_001191247.1	prolactin receptor isoform 5 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables lipid binding	EXP EXP: Inferred from Experiment	25846210	GOA
enables lipid binding	IPI IPI: Inferred from physical interaction	25846210	GOA
enables peptide hormone binding	IPI IPI: Inferred from physical interaction	7984244	GOA
enables prolactin receptor activity	IDA IDA: Inferred from direct assay	10585417	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12819209	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of Janus kinase activity	IDA IDA: Inferred from direct assay	10585417	GOA
involved in activation of transmembrane receptor protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	10585417	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	10585417	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	10585417	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRLR Protein Structure

EpoR_lig-bind

0
100
200
300
400
500
622 a.a.

Protein Preferred Names	Protein Names
prolactin receptor	hPRL receptor

PRLR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PRLR	P16471	PLPP6	Homo sapiens	Q8IY26	Validated Y2H	32296183
Intra	PRLR	P16471	YWHAZ	Homo sapiens	P63104	Pull Down	12819209
Intra	PRLR	P16471	INSIG2	Homo sapiens	Q9Y5U4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRLR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73696	Prolactin Receptor Protein, Human (HEK293, His)	NP_000940.1 (Q25-D234)	≥ 95%, as determined by reducing SDS-PAGE.

PRLR Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82666	Prolactin Receptor Antibody (YA2411)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hyperprolactinemia	Chiari-Frommel Syndrome Hyperprolactinaemia Familial Hyperprolactinemia HPRL Pregnancy-Related A-G Syndrome Familial Isolated Prolactin Receptor Deficiency
Multiple Fibroadenomas Of The Breast	MFAB Multiple Fibroadenoma Of The Breast Fibroadenomas, Breast, Multiple
Breast Disease	Breast Diseases
Cerebral Meningioma	Meningioma Of Cerebrum
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Infertility
Galactorrhea	Galactorrhea Not Associated With Childbirth Galactorrhea Associated With Childbirth
Lipid-Rich Breast Carcinoma
Acromegaly	Gigantism Growth Hormone Excess Pituitary Giant Somatotroph Adenoma Growth Hormone-Secreting Pituitary Adenoma
Prolactinoma	Prolactin-Producing Pituitary Gland Adenoma Prolactin-Secreting Pituitary Adenoma Forbes-Albright Syndrome Lactotroph Adenoma Prl-Secreting Pituitary Adenoma Prloma Pituitary Lactotrophic Adenoma Familial Prolactinoma Pituitary Adenoma, Prolactin-Secreting Prolactinoma Of Pituitary Gland PSPA
Breast Adenoma	Ademoma - Breast
Glycogen-Rich Carcinoma	Doid:0081028
Chromophobe Adenoma	Adenoma, Chromophobe Chromophobe Adenoma Of The Pituitary Gland Adenoma Chromophobe
Lipid-Rich Carcinoma
Functioning Pituitary Adenoma	Secretory Adenoma Of The Pituitary Gland Endocrine Active Pituitary Adenoma Secreting Pituitary Adenoma Pituitary Adenoma, Functioning
Breast Benign Neoplasm	Benign Tumour Of Breast Benign Neoplasm Of Female Breast
Thoracic Benign Neoplasm	Benign Neoplasm Of Thorax
Pituitary Gland Disease	Pituitary Diseases Pituitary Dysfunction Pituitary Disease Pituitary Deficiency Pituitary Disorders
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991358	XOMA-213	Inhibitor	98.46%	Phase 1
HY-P99881	Rolinsatamab talirine		/	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11163	PRLR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11411	PTP4A3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17413	Prlr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23867	Prlr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99238	Rolinsatamab		96.98%	Unkown
HY-P992449	REGN2878		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PRLR	RGD	RGD:3407
Felis catus	PRLR	VGNC	VGNC:69076
Bos taurus	PRLR	VGNC	VGNC:33346
Canis familiaris	PRLR	VGNC	VGNC:44994
Macaca mulatta	PRLR	VGNC	VGNC:76423
Mus musculus	PRLR	MGD	MGI:97763
Others	PRLR	NCBI