PRLR - prolactin receptor Gene

Homo sapiens

Also known as HPRL; MFAB; hPRLrI; RI-PRLR

Gene ID: 5618 | Gene type: protein coding

About PRLR

Cytogenetic location: 5p13.2 Genomic coordinates (GRCh38): 5:35,048,756-35,230,487 (from NCBI)

This gene has 20 transcripts (splice variants), 269 orthologues, 23 paralogues and is associated with 3 phenotypes. Biased expression in placenta (RPKM 18.9), endometrium (RPKM 11.6) and 8 other tissues.

Summary

This gene encodes a receptor for the anterior pituitary hormone, Prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the Prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of Prolactin in normal tissue and Cancer. [provided by RefSeq, Feb 2011]

PRLR Products(6)

mRNA	Protein	Name
NM_000949.7	NP_000940.1	prolactin receptor isoform 1 precursor
NM_001204314.2	NP_001191243.1	prolactin receptor isoform 6 precursor
NM_001204315.1	NP_001191244.1	prolactin receptor isoform 2 precursor
NM_001204316.1	NP_001191245.1	prolactin receptor isoform 3 precursor
NM_001204317.1	NP_001191246.1	prolactin receptor isoform 4 precursor
NM_001204318.1	NP_001191247.1	prolactin receptor isoform 5 precursor

PRLR Protein Structure

EpoR_lig-bind

0
100
200
300
400
500
622 a.a.

Protein Preferred Names

Protein Names

prolactin receptor

hPRL receptor

Recombinant PRLR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73696	Prolactin R Protein, Human (HEK293, His)	NP_000940.1 (Q25-D234)	≥95%

Related Diseases

Diseases

Alias

Hyperprolactinemia

Chiari-Frommel Syndrome	Hyperprolactinaemia
Familial Hyperprolactinemia	HPRL
Pregnancy-Related A-G Syndrome	Familial Isolated Prolactin Receptor Deficiency

Multiple Fibroadenomas Of The Breast

MFAB	Multiple Fibroadenoma Of The Breast
Fibroadenomas, Breast, Multiple

Breast Disease

Breast Diseases

Cerebral Meningioma

Meningioma Of Cerebrum

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Infertility

Galactorrhea

Galactorrhea Not Associated With Childbirth

Galactorrhea Associated With Childbirth

Lipid-Rich Breast Carcinoma

Acromegaly

Gigantism	Growth Hormone Excess
Pituitary Giant	Somatotroph Adenoma
Growth Hormone-Secreting Pituitary Adenoma

Prolactinoma

Prolactin-Producing Pituitary Gland Adenoma	Prolactin-Secreting Pituitary Adenoma
Forbes-Albright Syndrome	Lactotroph Adenoma
Prl-Secreting Pituitary Adenoma	Prloma
Pituitary Lactotrophic Adenoma	Familial Prolactinoma
Pituitary Adenoma, Prolactin-Secreting	Prolactinoma Of Pituitary Gland
PSPA

Breast Adenoma

Ademoma - Breast

Glycogen-Rich Carcinoma

Doid:0081028

Chromophobe Adenoma

Adenoma, Chromophobe	Chromophobe Adenoma Of The Pituitary Gland
Adenoma Chromophobe

Lipid-Rich Carcinoma

Functioning Pituitary Adenoma

Secretory Adenoma Of The Pituitary Gland	Endocrine Active Pituitary Adenoma
Secreting Pituitary Adenoma	Pituitary Adenoma, Functioning

Breast Benign Neoplasm

Benign Tumour Of Breast

Benign Neoplasm Of Female Breast

Thoracic Benign Neoplasm

Benign Neoplasm Of Thorax

Pituitary Gland Disease

Pituitary Diseases	Pituitary Dysfunction
Pituitary Disease	Pituitary Deficiency
Pituitary Disorders

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11163	PRLR Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PRLR	RGD	RGD:3407
Felis catus	PRLR	VGNC	VGNC:69076
Bos taurus	PRLR	VGNC	VGNC:33346
Canis familiaris	PRLR	VGNC	VGNC:44994
Macaca mulatta	PRLR	VGNC	VGNC:76423
Mus musculus	PRLR	MGD	MGI:97763
Others	PRLR	NCBI