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Prostatic Acid Phosphatase Antibody (YA5619)

(Synonyms: 5' NT; 5' nucleotidase; 5'-NT; 5'-nucleotidase; Acid phosphatase prostate; ACP 3; ACP3; acpP; Ecto 5' nucleotidase; Ecto-5'-nucleotidase; PAP; PPAP_HUMAN; Prostatic acid phosphatase; Prostatic acid phosphotase; Thiamine monophosphatase; TMPase)
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Prostatic Acid Phosphatase Antibody (YA5619) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Prostatic Acid Phosphatase.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG2b

  • Application:

    IHC-P, WB, ICC/IF, ELISA

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

  • Conjugation:
    Non-conjugated
  • Prostatic Acid Phosphatase Antibody (YA5619) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:200-1000 1:500-2000 1:100-500 1:1000-5000

Product Details

Description

Prostatic Acid Phosphatase Antibody (YA5619) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Prostatic Acid Phosphatase.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 68 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 58 kDa
Immunogen

Synthesized peptide derived from human PSAP AA range: 201-300

Purification

Protein G

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG2b

RRID

AB_3719061

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    Prostatic Acid Phosphatase is an A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma; Tyrosine phosphatase that acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling. In addition to its tyrosine phosphatase activity has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor; (Microbial infection) Forms amyloid beta-sheet fibrils in semen. These fibrils, termed SEVI (semen-derived enhancer of viral infection) capture HIV virions, attach them to target cells and enhance infection. SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea. Target cell attachment and enhancement of HIV infection is inhibited by surfen. Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection[1][2][3][4][5][6][7][8].

  • Subcellular Localization

    Secreted; Cell membrane; Single-pass type I membrane protein; Lysosome membrane; Single-pass type I membrane protein; Nucleus; Cytoplasm, cytosol

  • Expression


    Tissue_specificity:It is highly expressed in the prostate, limited to glandular and ductal epithelial cells. It is also expressed in the bladder, kidneys, pancreas, lungs, cervix, testes, and ovaries. It is weakly expressed in some pancreatic islet cells, squamous epithelium, pilosebaceous units, colonic neuroendocrine cells, and skin appendage structures. It is expressed at low levels in prostate cancer cells and tissues; it is also widely expressed. It is expressed in the sarcolemma of skeletal muscle.

  • Isoforms & Post-Translational Modification

    P15309 has 3 isomers: P15309-1: 44566 Da (predicted); P15309-2: 48336 Da (predicted); P15309-3: 40443 Da (predicted).
    N-glycosylated. High mannose content, partially sialylated and fucosylated biantennary complex. Also fucosylated with partially sialylated triantennary complex oligosaccharides;Proteolytically cleaved in seminal fluid to produce several peptides. Peptide PAPf39, the most prominent, forms amyloid beta-sheet fibrils, SEVI (semen-derived enhancer of viral infection)

  • Subunit

    Homodimer; dimer formation is required for phosphatase activity

  • SwissProt ID

    P15309

  • Gene ID
    55 [NCBI]
  • Synonyms

    5' NT; 5' nucleotidase; 5'-NT; 5'-nucleotidase; Acid phosphatase prostate; ACP 3; ACP3; acpP; Ecto 5' nucleotidase; Ecto-5'-nucleotidase; PAP; PPAP_HUMAN; Prostatic acid phosphatase; Prostatic acid phosphotase; Thiamine monophosphatase; TMPase

Prostatic Acid Phosphatase Antibody (YA5619) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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