ACP3 - acid phosphatase 3 Gene

Also Known as ACPP; 5'-NT; ACP-3; TM-PAP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55

About ACP3

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:132,317,407-132,368,302 (from NCBI)

This gene has 9 transcripts (splice variants), 165 orthologues and 5 paralogues. Restricted expression toward prostate (RPKM 1149.8).

Summary

This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]

ACP3 Products (3)

mRNA Protein Name
NM_001099.5 NP_001090.2 prostatic acid phosphatase isoform PAP precursor
NM_001134194.2 NP_001127666.1 prostatic acid phosphatase isoform TM-PAP precursor
NM_001292037.2 NP_001278966.1 prostatic acid phosphatase isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 5'-nucleotidase activity IDA
IDA: Inferred from direct assay
18940592 GOA
enables acid phosphatase activity IDA
IDA: Inferred from direct assay
10506173 GOA
enables acid phosphatase activity IMP
IMP: Inferred from mutant phenotype
8132635 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
18083097 GOA
enables lysophosphatidic acid phosphatase activity IDA
IDA: Inferred from direct assay
15280042 GOA
enables molecular adaptor activity EXP
EXP: Inferred from Experiment
19995078 GOA
enables phosphatase activity IMP
IMP: Inferred from mutant phenotype
18940592 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9705354 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
10639192 GOA
Biological Process GO Annotation Evidence References Source
involved in adenosine metabolic process IDA
IDA: Inferred from direct assay
18940592 GOA
involved in dephosphorylation IMP
IMP: Inferred from mutant phenotype
8132635 GOA
involved in positive regulation of adenosine receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
18940592 GOA
involved in regulation of sensory perception of pain IMP
IMP: Inferred from mutant phenotype
18940592 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
10639192 GOA
located in extracellular space IMP
IMP: Inferred from mutant phenotype
22389722 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
17658863 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACP3 Protein Structure

His_Phos_2

His_Phos_2: Histidine phosphatase superfamily (branch 2) (34 - 331)

  • 0
  • 100
  • 200
  • 300
  • 386 a.a.
Protein Preferred Names Protein Names

prostatic acid phosphatase

  • TMPase

ACP3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ACP3 P15309 ERBB2 Homo sapiens P04626
Genetic Interference
9705354
Intra
ACP3 P15309 ERBB2 Homo sapiens P04626
Phosphatase Assay
9705354
Intra
ACP3 P15309 ACP3 Homo sapiens P15309
Fluorescence
24657436
Intra
ACP3 P15309 ACP3 Homo sapiens P15309
Cosedimentation
18083097
Intra
ACP3 P15309 ACP3 Homo sapiens P15309
TEM
24657436
Intra
ACP3 P15309 ACP3 Homo sapiens P15309
CD
18083097
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ACP3 Proteins

Cat. No. Product Name Accession Purity
HY-P7817 Prostatic acid phosphatase/ACPP Protein, Human (HEK293, His, solution) AAH16344.1 (K33-D386) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7817A Prostatic acid phosphatase/ACPP Protein, Human (HEK293, His) P15309-2/NP_001127666.1 (K33-K382) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700619 Prostatic acid Phosphatase/ACPP Protein, Human (HEK293, GFP-His) P15309-2 (K33-K382) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P700620 Prostatic acid Phosphatase/ACPP Protein-VLP, Human (HEK293, His) P15309-2 (K33-I418) Purity analysis by SDS-PAGE is not available for VLP proteins.

ACP3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810625 Prostatic Acid Phosphatase Antibody (YA9887) WB, IHC-P Human
HY-P81961 Prostatic Acid Phosphatase Antibody (YA1706) WB, IHC-P, ICC/IF, IP Human
HY-P85927 Prostatic Acid Phosphatase Antibody (YA5619) IHC-P, WB, ICC/IF, ELISA Human, Mouse, Rat
HY-P86045 Prostatic Acid Phosphatase Antibody (YA5737) IHC-P, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Prostatitis
Clear Cell Adenocarcinoma

  • Mesonephroma

  • Water-Clear Cell Adenocarcinoma

  • Adenocarcinoma, Clear Cell

  • Malignant Mesonephroma

  • Mesonephroid Clear Cell Carcinoma

  • Mesonephroma, Malignant

  • Water-Clear Cell Carcinoma

  • Wolffian Duct Neoplasm

  • Adenocarcinoma Clear Cell

  • Mesonephric Tumor
Atypical Choroid Plexus Papilloma

  • Atypical Papilloma Of Choroid Plexus

  • Atypical Cpp
Cerebrovascular Benign Neoplasm
Phosphatase, Acid, Of Tissues

  • Lysosomal Acid Phosphatase

  • Acp3--Alpha Polypeptide
Choroid Plexus Cancer

  • Choroid Plexus Carcinoma

  • Choroid Plexus Neoplasms

  • Choroid Plexus Neoplasm

  • Tumor Of Choroid Plexus

  • Tumor Of The Choroid Plexus

  • Choroid Plexus Tumor

  • Choroid Plexus Tumors

  • Anaplastic Choroid Plexus Papilloma

  • Choroid Plexus Papilloma Nos

  • Papilloma Of Choroid Plexus

  • Plexus Choroideus Papilloma

  • Choroid Plexus Papilloma In Fourth Ventricle

  • Plexus Choroideus Papilloma In Fourth Ventricle
Prostatic Hyperplasia, Benign

  • Benign Prostatic Hyperplasia

  • BPH

  • Prostatic Hyperplasia
Prostatic Adenoma

  • Prostatic Hyperplasia

  • Adenoma - Prostate

  • Adenoma Of Prostate

  • Benign Adenoma Of Prostate

  • Prostate Adenoma

  • Benign Prostatic Hyperplasia
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Combined Oxidative Phosphorylation Deficiency 17

  • COXPD17

  • Combined Oxidative Phosphorylation Defect Type 17

  • Combined Oxidative Phosphorylation Deficiency, Type 17
Prostate Disease

  • Prostatic Diseases

  • Prostate Diseases
Papilloma Of Choroid Plexus

  • Choroid Plexus Papilloma

  • CPP

  • Childhood Choroid Plexus Papilloma

  • Papilloma Choroid Plexus

  • Papilloma, Choroid Plexus

  • Choroid Plexus Carcinoma
Endodermal Sinus Tumor

  • Yolk Sac Tumor

  • Endodermal Sinus Tumour

  • Hepatoid Yolk Sac Tumour

  • Infantile Embryonal Carcinoma

  • Yolk Sac Neoplasm

  • Yolk Sac Tumour
Cerebral Ventricle Cancer

  • Cerebral Ventricle Neoplasms

  • Cerebral Ventricle Neoplasm

  • Intraventricular Tumor Of Brain
Cerebrum Cancer

  • Cerebral Cancer

  • Neoplasm Of Cerebrum

  • Tumor Of Cerebrum

  • Malignant Neoplasm Of Cerebrum
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175023A OncoACP3 TFA Ligand 99.87% Unkown
HY-176567 ACP3 ligand 1 Ligand 99.84% Unkown
HY-RS00188 ACP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-175023 OncoACP3 Ligand / Unkown
HY-185120 ProX1-(SS)-DOTAGA_R / Unkown
HY-185120A ProX1-(SS)-DOTAGA / Unkown
HY-RS21289 Acp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27808 Acp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ACP3 RGD RGD:2023
Bos taurus ACP3 VGNC VGNC:52603
Canis familiaris ACP3 VGNC VGNC:54915
Mus musculus ACP3 MGD MGI:1928480
Macaca mulatta ACP3 VGNC VGNC:69385
Felis catus ACP3 VGNC VGNC:59528
Others ACP3 NCBI