PSMB4 (Proteasome subunit beta type 4 ) Antibody (YA8020)(PBS only)

Cat. No.: HY-P88336A: Data Sheet User Guide for Antibodies
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PSMB4 (Proteasome subunit beta type 4 ) Antibody (YA8020) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PSMB4 (Proteasome subunit beta type 4 ).

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

PSMB4 (Proteasome subunit beta type 4 ) Antibody (YA8020) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PSMB4 (Proteasome subunit beta type 4 ).

Host

Mouse

Molecular Weight

Predicted band size: 29 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P28070

Immunogen

Full length human recombinant protein of human PSMB4 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250
FC FC: Flow Cytometry	1:100

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1

Subcellular Localization：Cytoplasm,Nucleus

Expression：Induction: Up-regulated in fibrolamellar carcinomas

Isoforms & Post-Translational Modification：P28070: 264 amino acids, molecular weight 29204 Da.

Subunit：The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits (PubMed:25599644, PubMed:26133119, PubMed:27342858, PubMed:27428775, PubMed:27493187, PubMed:34711951, PubMed:9344905)

Synonyms

HN3; HsN3; PROS-26; PROS26

Documentation

User Guide for Antibodies (1077 KB)