PSMB4 (Proteasome subunit beta type 4 ) Antibody (YA8020)(PBS only)
(Synonyms: HN3; HsN3; PROS-26; PROS26)PSMB4 (Proteasome subunit beta type 4 ) Antibody (YA8020) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PSMB4 (Proteasome subunit beta type 4 ).
-
Host:
Mouse
-
Isotype:
IgG1
-
Application:
ICC/IF, FC
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Supplied in PBS, pH 7.4.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
|
|---|---|---|
| Dilution Ratio | 1:100-250 | 1:100 |
Product Details
PSMB4 (Proteasome subunit beta type 4 ) Antibody (YA8020) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PSMB4 (Proteasome subunit beta type 4 ).
-
Host Mouse
-
Species ReactivityHuman, Mouse, Rat
-
Calculated Molecular Weight Predicted band size: 29 kDa
Full length human recombinant protein of human PSMB4 produced in HEK293T cell.
Affinity purified
Non-conjugated
IgG1
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in PBS, pH 7.4.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
PSMB4 is a Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1
-
Subcellular Localization
Cytoplasm,Nucleus
-
Expression
Induction: Up-regulated in fibrolamellar carcinomas
-
Isoforms & Post-Translational Modification
P28070: 264 amino acids, molecular weight 29204 Da.
-
Subunit
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits (PubMed:25599644, PubMed:26133119, PubMed:27342858, PubMed:27428775, PubMed:27493187, PubMed:34711951, PubMed:9344905)
-
SwissProt ID
-
Synonyms
HN3; HsN3; PROS-26; PROS26
Documentation
Powered by Bioz
