PTPRE Antibody (YA8023)
(Synonyms: HPTPE; PTPE; R-PTP-EPSILON)PTPRE Antibody (YA8023) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PTPRE.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ICC/IF, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100-250 | 1:50-100 |
Product Details
PTPRE Antibody (YA8023) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PTPRE.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 80.5 kDa
Full length human recombinant protein of human PTPRE produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PTPRE is an Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function|Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake|Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+)
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Subcellular Localization
Cell membrane,Cytoplasm,Cytoplasm
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Expression
Tissue_Specificity: Expressed in giant cell tumor (osteoclastoma rich in multinucleated osteoclastic cells)
Induction: Up-regulated by 12-O-tetradecanoylphorbol-13-acetate (TPA) in HL-60 cells -
Isoforms & Post-Translational Modification
P23469 has three isomers: P23469-1: 80642 Da (predicted); P23469-2: 74595 Da (predicted); P23469-3: 71382 Da (predicted).
A catalytically active cytoplasmic form (p65) is produced by proteolytic cleavage of either isoform 1, isoform 2 or isoform 3丨Isoform 1 and isoform 2 are phosphorylated on tyrosine residues by tyrosine kinase Neu丨Isoform 1 is glycosylated -
Subunit
Monomer
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SwissProt ID
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Synonyms
HPTPE; PTPE; R-PTP-EPSILON
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