RAB7B Antibody (YA7625)
Based on 1 Customer Validation
RAB7B Antibody (YA7625) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to RAB7B.
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Host:
Rabbit
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Isotype:
IgG,Kappa
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Application:
WB, FC
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:1000-1:5000 | 1:100-1:500 |
Product Details
RAB7B Antibody (YA7625) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to RAB7B.
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Host Rabbit
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Clonality Monoclonal,Recombinant
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 22 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 22 kDa
The exact sequence is proprietary to MCE.
Endogenous
Protein A affinity purified
Non-conjugated
Unmodified
IgG,Kappa
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
RAB7B controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway
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Subcellular Localization
Late endosome,Lysosome,Golgi apparatus,Golgi apparatus, trans-Golgi network,Cytoplasmic vesicle, phagosome,Cytoplasmic vesicle, phagosome membrane
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Expression
Tissue_Specificity: Expressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte -
Isoforms & Post-Translational Modification
Q96AH8: 199 amino acids, molecular weight 22511 Da.
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SwissProt ID
Documentation
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